{"id":10164,"date":"2025-04-17T09:16:21","date_gmt":"2025-04-17T09:16:21","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=10164"},"modified":"2025-04-17T09:16:21","modified_gmt":"2025-04-17T09:16:21","slug":"preparation-and-in-vitro-in-vivo-study-using-quality-by-design-qbd-of-nimodipine-as-transdermal-gel","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=10164","title":{"rendered":"Preparation and In-vitro\/In-vivo Study using Quality by Design (QbD) of Nimodipine as Transdermal Gel"},"content":{"rendered":"

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The College of Pharmacy discussed the PhD dissertation entitled \u201cPreparation and In-vitro\/In-vivo Study using Quality by Design (QbD) of Nimodipine as Transdermal Gel\u201d by the student Samir Hasson Aziz Ramadhan and his supervisor, Assistant Professor Dr. Khalid Kadhem Al-Kinani, at the Pharmaceutics Department. The study aimed to prepare a gel for transdermal delivery of nimodipine as an alternative for the oral drug products, so that the gel is suitable for patients who cannot swallow. The study included the preparation of nimodipine-loaded transferosomes by thin evaporation\/hydration method through statistical optimization of processing parameters and ingredients quantities, then formulation of the optimized transferosomes as gel which was studied for quality, safety and comparative bioavailability versus oral nimodipine. Finally, the gel was subjected for stability study under different storage conditions. The study showed that the processing parameters and ingredients quantities during preparation of transferosomes are optimized so that their properties are improved then incorporated into gel which complied with compendial and other quality specifications. Furthermore, the gel was proved safe and its bioavailability enhanced more than three folds relatively to the oral product. The study recommended to conduct clinical trials for the prepared transferosomal gel to investigate the transdermal delivery of nimodipine through human skin. In addition, transferosomes may be formulated as patch with specific dose so that patients, specifically who cannot swallow oral drugs can get the best therapeutic benefits.<\/span><\/p>\n

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[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the PhD dissertation entitled \u201cPreparation and In-vitro\/In-vivo Study using Quality by Design (QbD) of … <\/i>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":10165,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7,5],"tags":[],"class_list":["post-10164","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion","category-last-news"],"yoast_head":"\nPreparation and In-vitro\/In-vivo Study using Quality by Design (QbD) of Nimodipine as Transdermal Gel - College of Pharmacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=10164\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and In-vitro\/In-vivo Study using Quality by Design (QbD) of Nimodipine as Transdermal Gel - 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