{"id":10492,"date":"2025-03-25T21:20:02","date_gmt":"2025-03-25T21:20:02","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=10492"},"modified":"2025-05-10T21:21:52","modified_gmt":"2025-05-10T21:21:52","slug":"formulation-in-vitro-and-in-vivo-characterization-of-flurbiprofen-loaded-terpesomal-gel-for-transdermal-delivery","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=10492","title":{"rendered":"Formulation, in- vitro and in- vivo characterization of flurbiprofen loaded terpesomal gel for transdermal delivery"},"content":{"rendered":"

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The College of Pharmacy discussed the MSc thesis entitled \u201cFormulation, in- vitro<\/em> and in- vivo<\/em> characterization of flurbiprofen loaded terpesomal gel for transdermal delivery\u201d by the student Zainab Mohammed Hameed and her supervisor, Assistant Professor Dr. Khalid Kadhem Al-Kinani, at the Pharmaceutics Department.<\/span><\/p>\n

The study aimed to develop an optimized transdermal delivery system for flurbiprofen to improve patient compliance and reduce gastrointestinal side effects associated with oral administration<\/span><\/p>\n

The study included the formulation of flurbiprofen into a terpene-enriched ultra-deformable liposomal system, termed “terpesome,” using the thin film hydration technique. A full factorial design was employed to create 23 formulations, optimizing based on vesicle size, polydispersity index (PDI), and entrapment efficiency. The final formula was incorporated into a Carbopol-934-based hydrogel for transdermal application<\/span><\/p>\n

The study concluded that the optimized formula had a vesicle size of 195 nm, a PDI of 0.3, an entrapment efficiency of 62%, and a zeta potential of -22.26 mV. The transdermal gel exhibited an 88% drug release over 7 hours, a flux rate of 6.5369 \u00b5g\/cm\u00b2\/h \u2014 significantly higher than the plain flurbiprofen gel’s 0.4981 \u00b5g\/cm\u00b2\/h \u2014 and demonstrated safety and efficacy in an albino rat model with albumin-induced paw edema.<\/span><\/p>\n

The study recommended further investigation of the formulation\u2019s long-term stability and clinical trials to evaluate its effectiveness and safety in human subjects, supporting its potential as an alternative route for flurbiprofen administration.<\/span><\/p>\n

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