{"id":16187,"date":"2026-05-07T04:09:23","date_gmt":"2026-05-07T04:09:23","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=16187"},"modified":"2026-05-25T04:10:58","modified_gmt":"2026-05-25T04:10:58","slug":"formulation-and-evaluation-of-loratadine-loaded-ocular-film","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=16187","title":{"rendered":"Formulation and Evaluation of Loratadine Loaded Ocular Film"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The College of Pharmacy discussed the MSc thesis entitled <em>\u201cFormulation and Evaluation of Loratadine Loaded Ocular Film\u201d<\/em> by the student <strong>Rasha Hameed Khalid<\/strong> and the supervisor, Assistant Professor <strong>Lina Murad Thomas,<\/strong> at the Pharmaceutics Department.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The study aimed to develop and evaluate a topical ophthalmic drug delivery system containing loratadine incorporated into a polymeric ocular film with mucoadhesive and sustained-release properties in order to prolong the residence time of the formulation on the ocular surface, enhance bioavailability, and reduce the frequency of drug administration.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The study included the preparation of ocular films using the solvent casting technique, employing hydroxypropyl methylcellulose (HPMC) as the film-forming polymer, along with various mucoadhesive polymers such as sodium alginate, sodium hyaluronate, and polyvinylpyrrolidone. Propylene glycol was used as a plasticizer. The study also included the evaluation of the physical and mechanical properties of the prepared films, as well as swelling behavior, mucoadhesion, and drug release characteristics, in addition to cytotoxicity and ocular irritation studies.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The study concluded that the optimized formulation exhibited good drug content uniformity, appropriate pH, suitable thickness, and satisfactory mechanical properties, along with high mucoadhesive strength and sustained drug release for up to 12 hours. Furthermore, biological studies demonstrated that the ocular film was non-toxic and non-irritant to the eye, indicating its potential as a promising long-acting ocular drug delivery system for loratadine.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The study recommended conducting further clinical and long-term stability studies to more comprehensively evaluate the efficacy and safety of the loratadine-loaded ocular film, as well as to explore its potential for future industrial-scale production.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_37694\" class=\"cz_grid_p cz_37694\"><div class=\"cz_grid cz_grid_1 clr cz_grid_c3 cz_grid_1_no_title cz_grid_1_mid tac\"><div class=\"cz_grid_item cz_grid_first\"><\/div><div class=\"cz_grid_item \"><div data-title=\"\u0645\u0646\u0627\u0642\u0634\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0631\u0634\u0627 (1)\"><a class=\"cz_grid_link \" 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src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2026\/05\/\u0645\u0646\u0627\u0642\u0634\u0629-\u0645\u0627\u062c\u0633\u062a\u064a\u0631-\u0631\u0634\u0627-5-600x468.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"\u0645\u0646\u0627\u0642\u0634\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0631\u0634\u0627 (5)\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"\u0645\u0646\u0627\u0642\u0634\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0631\u0634\u0627 (6)\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2026\/05\/\u0645\u0646\u0627\u0642\u0634\u0629-\u0645\u0627\u062c\u0633\u062a\u064a\u0631-\u0631\u0634\u0627-6.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"468\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2026\/05\/\u0645\u0646\u0627\u0642\u0634\u0629-\u0645\u0627\u062c\u0633\u062a\u064a\u0631-\u0631\u0634\u0627-6-600x468.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"\u0645\u0646\u0627\u0642\u0634\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0631\u0634\u0627 (6)\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"\u0645\u0646\u0627\u0642\u0634\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0631\u0634\u0627 (7)\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2026\/05\/\u0645\u0646\u0627\u0642\u0634\u0629-\u0645\u0627\u062c\u0633\u062a\u064a\u0631-\u0631\u0634\u0627-7.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"468\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2026\/05\/\u0645\u0646\u0627\u0642\u0634\u0629-\u0645\u0627\u062c\u0633\u062a\u064a\u0631-\u0631\u0634\u0627-7-600x468.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"\u0645\u0646\u0627\u0642\u0634\u0629 \u0645\u0627\u062c\u0633\u062a\u064a\u0631 \u0631\u0634\u0627 (7)\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the MSc thesis entitled \u201cFormulation and Evaluation of Loratadine Loaded Ocular Film\u201d by the &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=16187\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":16190,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[7,5],"tags":[],"class_list":["post-16187","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dissuasion","category-last-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Formulation and Evaluation of Loratadine Loaded Ocular Film - College of Pharmacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=16187\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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