{"id":1662,"date":"2023-01-25T22:04:38","date_gmt":"2023-01-25T22:04:38","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=1662"},"modified":"2023-01-25T22:04:38","modified_gmt":"2023-01-25T22:04:38","slug":"discussion-evaluating-the-protective-effect-of-omega-7-against-acetaminophen-induced-liver-toxicity-in-rats","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=1662","title":{"rendered":"Discussion Evaluating the Protective Effect of Omega-7 Against Acetaminophen Induced Liver Toxicity in Rats"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The Faculty of Pharmacy discussed the Master\u2019s Degree thesis, &#8220;Evaluating the Protective Effect of Omega-7 Against Acetaminophen Induced Liver Toxicity in Rats &#8221; by <strong>Hadeel Ali Hameed <\/strong>and her supervisor, <strong>Assist. Prof. Dr. Ali Faris Hassan<\/strong> in the Pharmacology and Toxicology Department.\u00a0The thesis aimed to evaluate the protective effect of omega-7 against acetaminophen-induced hepatotoxicity in rats by measuring the following biomarkers: serum alanine-aminotransferase, aspartate aminotransferase, alkaline phosphatase, tumor necrosis factor-alpha, and interleukin-10, while hepatic tissue homogenates were used for the estimation of: superoxide dismutase, catalase, glutathione peroxidase, glutathione and malondialdehyde. Furthermore, a histological examination of rats\u2019 liver sections was also performed.\u00a0 The results showed that treatment of rats with omega-7 produced a significant reduction in levels of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase and a significant decline in levels of inflammatory cytokines tumor necrosis factor-alpha and interleukin-10 compared to acetaminophen group. Moreover, treatment of rats with omega-7 showed significant elevations in the levels of\u00a0 \u00a0superoxide dismutase, catalase, and reduced glutathione, along with a significant reduction in the level of malondialdehyde compared to the acetaminophen group. The results of histopathological examination showed marked improvements in the appearance of the liver section of the omega-7 treated groups, as compared to the acetaminophen group.\u00a0The results confirmed that Omega-7 has protective effects against acetaminophen-induced hepatotoxicity in rats. These positive effects could be attributable to omega-7&#8217;s potent anti-inflammatory and antioxidant properties.\u00a0<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1663 size-large\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/01\/7-1-1024x768.jpg\" alt=\"\" width=\"1024\" height=\"768\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/01\/7-1-1024x768.jpg 1024w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/01\/7-1-300x225.jpg 300w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/01\/7-1-768x576.jpg 768w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/01\/7-1-600x450.jpg 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/01\/7-1.jpg 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Faculty of Pharmacy discussed the Master\u2019s Degree thesis, &#8220;Evaluating the Protective Effect of Omega-7 Against Acetaminophen Induced Liver Toxicity &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=1662\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":1663,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7],"tags":[],"class_list":["post-1662","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - 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