{"id":1691,"date":"2023-02-03T17:52:01","date_gmt":"2023-02-03T17:52:01","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=1691"},"modified":"2023-02-03T17:52:34","modified_gmt":"2023-02-03T17:52:34","slug":"discussion-of-formulation-and-in-vitro-evaluation-of-surfactants-free-reconstituted-dry-oral-emulsions-of-lamotrigine","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=1691","title":{"rendered":"Discussion of Formulation and in vitro Evaluation of Surfactants Free Reconstituted Dry Oral Emulsions of Lamotrigine"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The College of Pharmacy at the University of Baghdad, discussed the master&#8217;s thesis tagged (Formulation and in vitro Evaluation of Surfactants Free Reconstituted Dry Oral Emulsions of Lamotrigine) for the student in the Pharmaceutical Sciences Department, Ali Sattar Kurgee, and his supervisor, Prof. Dr. Mowafaq M. Ghareeb. The present study aimed to prepare surfactant free reconstituted dry oral emulsions of lamotrigine using natural stabilizers like \u03b2-Cyclodextrin, Pectin and Chitosan instead of synthetic surfactants. \u00a0The effects of different variables on solubility and dissolution rate of dry emulsion were studied, such as type and percent of stabilizers, percent of oil, and characterized for their drug content, drug solubility, and <em>in-vitro<\/em> drug dissolution\u00a0\u00a0(post drying study ) in comparison with pure drug and conventional dry emulsion. Twenty formulas of Surfactant free dry oral emulsion were prepared by changing the percent of polymer with fixing type or changing type and changing the percent of oil with fixing the type of stabilizer and changing its percent.\u00a0\u00a0 \u00a0The best results were obtained by the F8 formula which was formulated by the use of \u03b2-Cyclodextrin (12g) and Corn oil (31.4g) which gave high drug content (99.3%), good release of drug (99.53%) in 0.1 N HCL (pH 61.2) within 120 min.\u00a0These dry powders also show good stability after being stored them for two months at different temperatures.\u00a0\u00a0So, it can be concluded that the solubility and dissolution rate of LMT are efficiently improved when it\u2019s prepared as a Surfactant-free dry oral emulsion. Moreover, green engineering by using natural stabilizers instead of synthetic surfactants can be considered a successful and efficient technique for improving solubility and dissolution rate of hydrophobic drugs and preparing products that are safe for the environment.<\/span><\/p>\n<p>\u00a0[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_87986\" class=\"cz_grid_p cz_87986\"><div class=\"cz_grid cz_grid_1 clr cz_grid_c4 cz_grid_1_no_title cz_grid_1_mid tac cz_tooltip cz_grid_1_no_title\"><div class=\"cz_grid_item cz_grid_first\"><\/div><div class=\"cz_grid_item \"><div data-title=\"1\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/02\/1.png\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/02\/1-600x600.png\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"1\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/02\/1-600x600.png 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/02\/1-150x150.png 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The College of Pharmacy at the University of Baghdad, discussed the master&#8217;s thesis tagged (Formulation and in vitro Evaluation &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=1691\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":1692,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[3,7],"tags":[],"class_list":["post-1691","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-postgraduate-studies-discussions"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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