{"id":17119,"date":"2026-09-19T10:40:19","date_gmt":"2026-09-19T10:40:19","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=17119"},"modified":"2026-09-19T10:40:19","modified_gmt":"2026-09-19T10:40:19","slug":"preparation-and-in-vitro-in-vivo-evaluation-of-bromhexine-hydrochloride-loaded-nanomicelles-for-nebulized-pulmonary-delivery","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=17119","title":{"rendered":"Preparation and In Vitro\/In Vivo Evaluation of Bromhexine Hydrochloride Loaded Nanomicelles for Nebulized Pulmonary Delivery"},"content":{"rendered":"

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The College of Pharmacy discussed the PhD dissertation entitled “Preparation and In Vitro\/In Vivo Evaluation of Bromhexine Hydrochloride Loaded Nanomicelles for Nebulized Pulmonary Delivery”, by the student Hayder Imad Jabar and the supervisor, Professor Dr. Mowafaq Mohammed Ghareeb, at the Pharmaceutics Department.<\/span><\/p>\n

The study aimed to prepare and evaluate bromhexine hydrochloride-loaded mixed nanomicelles as a nebulizable pulmonary drug-delivery system to improve local pulmonary delivery and reduce unnecessary gastrointestinal and systemic exposure.<\/span><\/p>\n

The study included the preparation of 27 nanomicelle and mixed-micelle dispersions by thin-film hydration using Soluplus, Tyloxapol, Tween 80, and TPGS; their optimization based on particle size, PDI, zeta potential, entrapment efficiency, and drug loading; characterization of the optimized formula by physicochemical, thermal, and morphological studies, in vitro release, and stability studies; aerosol performance evaluation using a Next Generation Impactor; and an in vivo pharmacokinetic and lung distribution study in mice with bioimaging and histopathological examination.<\/span><\/p>\n

The results showed that the optimized formula (drug:Soluplus:Tyloxapol at a ratio of 1:10:5) exhibited a particle size of 71.96 nm and an entrapment efficiency of 97.90%, suitable aerosol performance (MMAD = 3.987 \u00b5m, FPF = 60.25%), and at a nebulized dose of 0.20 mg\/kg (one tenth of the oral dose) achieved a markedly higher lung Cmax, prolonged the lung half-life to 20.5 h versus the oral route, raised the lung-targeting index from 1.13 to 3.61 with a relative lung bioavailability of 3646%, and showed predominant lung localization by bioimaging with confirmed initial biosafety on histopathology, in addition to a Level A in vitro\u2013in vivo correlation.<\/span><\/p>\n

The study recommended conducting long-term stability studies and scale-up studies assessing batch reproducibility, performing chronic inhalation studies in respiratory disease animal models for long-term pulmonary safety and extended mucolytic efficacy, carrying out deeper mechanistic studies on drug release, cellular uptake, and biodistribution of the carriers, and completing a comprehensive preclinical regulatory package including validated analytical procedures and GLP-compliant repeat-dose toxicity studies as a prelude to clinical trials.<\/span><\/p>\n

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[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the PhD dissertation entitled “Preparation and In Vitro\/In Vivo Evaluation of Bromhexine Hydrochloride Loaded … <\/i>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":17122,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,5,7],"tags":[],"class_list":["post-17119","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-last-news","category-postgraduate-studies-discussions"],"yoast_head":"\nPreparation and In Vitro\/In Vivo Evaluation of Bromhexine Hydrochloride Loaded Nanomicelles for Nebulized Pulmonary Delivery - College of Pharmacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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