{"id":2039,"date":"2023-03-24T12:51:30","date_gmt":"2023-03-24T12:51:30","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=2039"},"modified":"2023-03-24T12:54:02","modified_gmt":"2023-03-24T12:54:02","slug":"synthesis-and-biological-evaluation-of-novel-benzodipyrone-based-derivatives","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=2039","title":{"rendered":"((Synthesis and Biological Evaluation of Novel Benzodipyrone Based Derivatives))"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The Faculty of Pharmacy discussed the Dotor\u2019s Degree thesis, tagged&#8221; <strong>Synthesis and Biological Evaluation of Novel Benzodipyrone Based Derivatives<\/strong>&#8221; by <strong>Salah Hassan Zain Al Abdeen <\/strong>and the supervisor, <strong>Assist. Prof. Dr. Shihab Hattab Mutlag<\/strong> and <strong>Prof. Dr. Yasser Fakri Mustafa <\/strong>in the Pharmaceutical Chemistry Department.\u00a0The thesis aimed to synthesize A novel series of benzodipyrone derivatives using a novel benzodipyrone core precursor, and their various biological activities were investigated. The pharmacological profiles of these benzodipyrones have almost been fully characterized by this study, which has clarified their therapeutic effects and provided direction for future efforts to improve them.\u00a0The results of screening the anticancer activity showed that, when compared to other prepared compounds, the fluorinated derivatives (<strong>SY4, SY11<\/strong>, and <strong>SY18<\/strong>)\u00a0 had the most potent and widespread anticancer activity, with IC<sub>50<\/sub> values that were close to the norm, particularly against the MCF-7 and HeLa cell lines. The synthesized chemicals were shown to be safer than the standard in terms of cytosafety. The fluorinated derivatives have the best safety record out of all of them.\u00a0The findings from the analysis of the antimicrobial activities produced a number of intriguing findings. First, among other synthesized\u00a0compounds, the chlorinated derivatives (<strong>SY5, SY12<\/strong>, and <strong>SY19<\/strong>) demonstrated the strongest antibacterial activity against all of the evaluated pathogenic aerobic gram-negative bacterial strains. Second, when compared to the standard, the synthesized compounds displayed a better level of safety for the evaluated non-pathogenic aerobic gram-negative bacterium model.. Third, among other synthesized compounds, the methoxy derivatives (<strong>SY2, SY9<\/strong>, and <strong>SY16<\/strong>)\u00a0 demonstrated the highest antibacterial activity toward all of the evaluated harmful anaerobic bacterial strains. Finally, more than half of the synthesized compounds outperformed the standard in their good antifungal activity against the two pathogenic fungal strains tested, with the benzodipyrone core precursors (<strong>SY1, SY8<\/strong> and <strong>SY15<\/strong>) being the most effective .According to the results of detecting antidiabetic activity, the methoxy derivatives of\u00a0 benzodipyrone (<strong>SY2, SY9<\/strong>, and <strong>SY16<\/strong>) showed the highest suppressing impact against yeast-\u03b1-glucosidase and porcine-\u03b1-amylase enzymes compared to the other synthesized compounds, with potency similar to the standard.\u00a0The antioxidative activity scan revealed that the methoxy derivatives of benzodipyrone cores (<strong>SY2, SY9<\/strong>, and <strong>SY16<\/strong>) had the strongest uptake effect on DPPH and hydroxyl free radicals, particularly in comparison to the synthesized benzodipyrone derivatives.\u00a0<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_29041\" class=\"cz_grid_p cz_29041\"><div class=\"cz_grid cz_grid_1 clr cz_grid_c3 cz_grid_1_no_title cz_grid_1_mid tac cz_tooltip cz_grid_1_no_title\"><div class=\"cz_grid_item cz_grid_first\"><\/div><div class=\"cz_grid_item \"><div data-title=\"1\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/1-6.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/1-6-600x600.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"1\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/1-6-600x600.jpg 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/1-6-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"2\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/2-3.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/2-3-600x600.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"2\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/2-3-600x600.jpg 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/2-3-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"3\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/3-2.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/3-2-600x600.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"3\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/3-2-600x600.jpg 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/03\/3-2-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The Faculty of Pharmacy discussed the Dotor\u2019s Degree thesis, tagged&#8221; Synthesis and Biological Evaluation of Novel Benzodipyrone Based Derivatives&#8221; &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=2039\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":2044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[3,7],"tags":[],"class_list":["post-2039","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - 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