{"id":3663,"date":"2023-07-26T23:47:41","date_gmt":"2023-07-26T23:47:41","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3663"},"modified":"2023-08-18T23:51:41","modified_gmt":"2023-08-18T23:51:41","slug":"discussion-the-hepatoprotective-effect-of-triple-omega-3-6-9-against-acute-acetaminophen-induced-hepatic-injury-as-compared-with-the-effect-of-n-acetylcysteine-in-mice","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3663","title":{"rendered":"Discussion \u00a0the hepatoprotective effect of triple omega 3-6-9 against acute acetaminophen-induced hepatic injury as compared with the effect of N-acetylcysteine in mice"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The Faculty of Pharmacy discussed the Master\u2019s Degree thesis, tagged &#8220;Hepatoprotective effect of triple omega 3-6-9 against acute acetaminophen-induced hepatic injury as compared with the effect of N-acetylcysteine in mice.&#8221; by <strong>Yousif Hashim Mohammed<\/strong>\u00a0and his supervisor, <strong>Assist. Prof. Dr. Ali Faris Hassan <\/strong>in the Department of Pharmacology and Toxicology on July, 23, 2023.\u00a0This study was designed to investigate the possible hepatoprotective effect of triple omega 3-6-9 against acute acetaminophen-induced hepatic injury as compared with the effect of N-acetylcysteine in mice by evaluating liver function enzymes and some selected inflammatory markers in rats\u2019 serum, in addition to rats\u2019 brain tissue histopathology.\u00a0The results showed that the mice in Group 2 (positive control) after a single intraperitoneal injection with acetaminophen produced a significant increase in the serum levels of tumor necrosis factor alpha, interleukin 10, interleukin 1b, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase and produced a significant decrease in the reduced glutathione, glutathione peroxidase, and superoxide dismutase in the liver, with a significantly increased hepatic malondialdehyde level as compared with Group 1 (negative control). The mice in Group 3 (treated with triple omega 3-6-9 at dose 50 mg\/kg ) ,Group 4 (treated with triple omega 3-6-9 at dose 100 mg\/kg) and Group 5 (treated with N-acetylcysteine (100 mg\/kg) prior to acetaminophen produced a significant decrease in the serum levels of tumor necrosis factor alpha , interleukin 10, interleukin 1b, alanine aminotransferase,\u00a0 aspartate aminotransferase, and alkaline phosphatase and produced a significant increase in the reduced glutathione, glutathione peroxidase, and superoxide dismutase in the liver with a significantly decreased hepatic malondialdehyde level as compared with Group 2 (positive control) , while mice in Group 5 as compared with Group 1 produced a significant different in level of aspartate aminotransferase, interleukin 10, interleukin 1b, superoxide dismutase , glutathione, glutathione peroxidase. In comparison to Group 2,observable characteristics of liver sections of the pretreatment groups with triple omega 3-6-9 and N-acetylcysteine exhibited significant improvement, as determined by the findings of the histological inspection.\u00a0Overall, this study clearly showed the administration of triple omega 3-6-9 to mice led to a reduction in the toxicity of acetaminophen. These results indicate that triple omega 3-6-9 provides protection against the toxicity that is produced by acetaminophen in the liver. One possible explanation for this is that it possesses anti-inflammatory and antioxidant effects.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_75409\" class=\"cz_grid_p cz_75409\"><div class=\"cz_grid cz_grid_1 clr cz_grid_c2 cz_grid_l2 cz_grid_1_no_title cz_grid_1_mid tac cz_tooltip cz_grid_1_no_title\"><div class=\"cz_grid_item cz_grid_first\"><\/div><div class=\"cz_grid_item \"><div data-title=\"1\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/08\/1-5.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"500\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/08\/1-5-1200x500.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"1\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"2\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/08\/2-5.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"500\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/08\/2-5-1200x500.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"2\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"3\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/08\/3-4.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"500\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/08\/3-4-1200x500.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"3\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"4\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/08\/4-3.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"500\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/08\/4-3-1200x500.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"4\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The Faculty of Pharmacy discussed the Master\u2019s Degree thesis, tagged &#8220;Hepatoprotective effect of triple omega 3-6-9 against acute acetaminophen-induced &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3663\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":3665,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7],"tags":[],"class_list":["post-3663","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - 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