{"id":3707,"date":"2023-08-10T21:35:08","date_gmt":"2023-08-10T21:35:08","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3707"},"modified":"2023-09-01T21:37:54","modified_gmt":"2023-09-01T21:37:54","slug":"the-faculty-of-pharmacy-discussed-the-preparation-and-evaluation-of-a-cilnidipine-nanoparticle-as-an-oral-film","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3707","title":{"rendered":"The Faculty of Pharmacy discussed the preparation and evaluation of a cilnidipine nanoparticle as an oral film."},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The Faculty of Pharmacy discussed the preparation and evaluation of a cilnidipine nanoparticle in an oral film by Ruaa Abdullah Saadoon and his supervisor, Assistant Prof. Dr. Hanan Jalal Kassab, in the Department of Pharmaceutics on August 8, 2023.\u00a0The aim of this study is to formulate and characterize cilnidipine as nanoparticles using various stabilizers and co-stabilizers in an attempt to enhance the water dispersibility of cilnidipine, which results in an improvement in the dissolution rate and the subsequent preparation of fast-dissolving film to achieve immediate release, a rapid onset of action, and improved patient compliance.\u00a0The selected formula was according to parameters of particle size, polydispersity index, zeta potential, entrapment efficiency, and in-vitro drug release.\u00a0The present study involved an initial screening process to identify the optimal polymer 15 formula (P1-P15) for cilnidipine nanoparticles. This was achieved through the utilization of a solvent-anti-solvent method, where various carriers (Soluplus\u00ae, Poloxamer 188, PVA cold, PVP K30, HPMC E5) were employed in different ratios. The chosen polymer carriers were subsequently combined with co-stabilizers (PEG200 or glycerol) in varying proportions, resulting in the preparation of 36 distinct formulas (N1\u2013N36).\u00a0The optimized formula (N4) containing Cilindipine (5 mg), Suloplus (5 mg), and Glycerol (1.19 l) had a particle size and entrapment efficiency of (88.89) nm and (95.84), respectively.\u00a0The compatibility and crystallinity investigation revealed that cilnidipine was compatible with the other excipients used in the research, and the drug molecule was found to be in an amorphous state within the lipid matrix. Examination of particle shape and surface morphology demonstrated almost spherical nanoparticles.\u00a0The in vitro drug release profile of formula (N4) illustrates a biphasic pattern in which a burst release is followed by a persistent phase over a 30-minute release period, with an estimated percent of the medication reaching close to 100%.\u00a0The best formula (N4) was incorporated in PVAc and HPMC E5 with different concentrations. The prepared film formulas were evaluated for their appearance, pH, drug content, and in vitro dissolution at pH 6.8.\u00a0In conclusion, solvent-anti-solvent precipitation produced CLD nanoparticles with an enhanced dissolution rate, and soluplus polymer was the optimal polymer. Soluplus with glycerol at 5:5:1.19 produced the smallest particle size, less than 100 nm.\u00a0PVA and HPMC E5 are good candidates for producing fast-dissolving films due to their excellent in vitro release and disintegration, but PVA showed better appearance and less stickiness, and the combination showed faster disintegration and release.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_92434\" class=\"cz_grid_p cz_92434\"><div class=\"cz_grid cz_grid_1 clr cz_grid_c3 cz_grid_1_no_title cz_grid_1_mid tac cz_tooltip cz_grid_1_no_title\"><div class=\"cz_grid_item cz_grid_first\"><\/div><div class=\"cz_grid_item \"><div data-title=\"1\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/09\/1.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/09\/1-600x600.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"1\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/09\/1-600x600.jpg 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/09\/1-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"2\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/09\/2.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/09\/2-600x600.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"2\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/09\/2-600x600.jpg 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/09\/2-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"3\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/09\/3.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"565\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/09\/3-600x565.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"3\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The Faculty of Pharmacy discussed the preparation and evaluation of a cilnidipine nanoparticle in an oral film by Ruaa &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3707\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":3708,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7],"tags":[],"class_list":["post-3707","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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