{"id":3875,"date":"2023-09-19T06:17:15","date_gmt":"2023-09-19T06:17:15","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3875"},"modified":"2023-09-19T06:17:15","modified_gmt":"2023-09-19T06:17:15","slug":"discussion-the-synthesis-and-preliminary-pharmacological-evaluation-of-new-furanyl-pyrazoline-derivatives","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3875","title":{"rendered":"Discussion the Synthesis and Preliminary Pharmacological Evaluation of New Furanyl-Pyrazoline Derivatives"},"content":{"rendered":"

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The Faculty of Pharmacy discussed the Master\u2019s Degree thesis, entitled Synthesis and Preliminary Pharmacological Evaluation of New Furanyl-Pyrazoline Derivatives, by Shaymaa Kanaan Kamil and the supervisor, Assist. Prof. Tagreed N. A. Omar, in the Pharmaceutical Chemistry Department. The study aimed to Nine new pyrazoline-furanyl derivatives (4(a-i)(3-(furan-2-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-3-phenylpropan-2-one)\u00a0were synthesized and evaluated for their anti-inflammatory and antimicrobial activity. The synthesis of the proposed compounds was successfully achieved by the stated procedures, and the reaction progress was monitored by thin-layer chromatography. The synthesized compounds were also characterized by FTIR and 1HNMR. The target synthesized compounds had been synthesized in four steps: The first step included the synthesis of different chalcones using Cross-Aldol Condensation (Claisen-Schmidt) 1(a-g) ((E)-3-(furan-2-yl)-1-phenylprop-2-en-1-one); the\u00a0second step included the synthesis of pyrazolines 2(a-g) (3-(furan-2-yl)-5-phenyl-4,5-dihydro-1H-pyrazole); the\u00a0third step included the synthesis of 3(I-II) (2-chloro-N-phenyl acetamide and 2-chloro-N-(4-nitrophenyl) acetamide); and\u00a0finally, the fourth step involved the synthesis of pyrazoline-aniline derivatives 4(a-i) (1-(3-(furan-2-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-3-phenylpropan-2-one) as final products. The pharmacological activities of the final synthesized compounds as anti-inflammatory agents were tested in vivo using the egg-white-induced edema method, and antimicrobial activity was evaluated using a well diffusion method against gram-negative (E. coli and P. aeruginosa) and gram-positive (S.\u00a0aureus and S. pyogenes).\u00a0Also, the antifungal activity was tested against\u00a0Candida albicans. All compounds reduced the edema compared with propylene glycol at 50% v\/v as a control. The compounds with electron withdrawal groups (Br, Cl, and NO2) 4a, 4b, and 4e showed anti-inflammatory activity compared to diclofenac sodium as a standard drug, while compounds with double electron withdrawal groups (Br and NO2) 4h and 4i showed stronger anti-inflammatory activity than diclofenac sodium. For antibacterial activity, the compounds have moderate to high antibacterial activity against gram-positive bacteria and gram-negative bacteria. Compounds with electron withdrawal groups (Br, Cl, and NO2) (4a, 4b, 4e, 4h, and 4i) showed more antibacterial activity against gram-negative bacteria than gram-positive bacteria, while compounds with electron-donating groups (NH2\u00a0and OH) (4f and 4g) showed more activity against gram-negative bacteria. Compounds with functional groups (Br, NO2, and OH) 4a, 4e, 4g, and 4i showed significant inhibition of fungal growth in comparison with fluconazole as a standard antifungal drug.<\/span><\/p>\n

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[vc_row][vc_column][vc_column_text] The Faculty of Pharmacy discussed the Master\u2019s Degree thesis, entitled Synthesis and Preliminary Pharmacological Evaluation of New Furanyl-Pyrazoline Derivatives, … <\/i>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":3878,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7],"tags":[],"class_list":["post-3875","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion"],"yoast_head":"\nDiscussion the Synthesis and Preliminary Pharmacological Evaluation of New Furanyl-Pyrazoline Derivatives - College of Pharmacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3875\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discussion the Synthesis and Preliminary Pharmacological Evaluation of New Furanyl-Pyrazoline Derivatives - 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