{"id":3897,"date":"2023-09-25T21:47:06","date_gmt":"2023-09-25T21:47:06","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3897"},"modified":"2023-09-25T21:47:06","modified_gmt":"2023-09-25T21:47:06","slug":"discussion-the-evaluation-of-the-possible-renoprotective-effect-of-omega3-6-9-against-cisplatin-induced-nephrotoxicity-in-mice","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3897","title":{"rendered":"Discussion the Evaluation of the Possible Renoprotective Effect of Omega3-6-9 Against Cisplatin-Induced Nephrotoxicity in Mice"},"content":{"rendered":"

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The Faculty of Pharmacy discussed the Master\u2019s Degree thesis, tagged \u201cEvaluation of the Possible Renoprotective Effect of Omega3-6-9 Against Cisplatin-Induced Nephrotoxicity in Mice<\/strong>\u201d. <\/span>Saja Kareem Abdulhussen<\/strong> and the supervisor, Assistant Prof. Dr. <\/i>Ali Faris Hassan, <\/strong>in the Department of Pharmacology and Toxicology .<\/span>This study is designed to investigate the possible renoprotective effect of omega 3-6-9 against acute cisplatin-induced nephrotoxicity in mice by evaluating kidney function markers, some inflammatory markers, and oxidative markers. The result showed that a single intraperitoneal injection with cisplatin produced a significant increase in serum creatinine,uric acid, lactate dehydrogenase, and blood urea nitrogen, a significant increase in renal tissue tumor necrosis factor alpha, interleukin-1B, and interleukin-6, and a significant decrease in superoxide dismutase, glutathione peroxidase, and reduced glutathione in renal, with an increased renal malondialdehyde level compared with group 1 (negative control). The mice in Group 3 (treated with triple omega 3-6-9 at dose 50 mg\/kg ) ,Group 4 (treated with triple omega 3-6-9 at dose 100 mg\/kg) and Group 5 (treated with alphatocopherol (100 mg\/kg) prior to cisplatin produced a significant decrease in the serum levels of creatinine ,uric acid ,lactatedehydrogenase and blood urea nitrogen and produced a significant decrease tumor necrosis factor alpha , interleukin 6, interleukin 1b, and produced a significant increase in the reduced glutathione, glutathione peroxidase, and superoxide dismutase in renal tissue with a significantly decreased renal malondialdehyde level as compared with Group 2 (positive control) , observable characteristics of renal sections of the pretreatment groups with triple omega 3-6-9 and alphatocopherol exhibited significant improvement, as determined by the findings of the histological inspection. Overall, this study clearly showed the administration of triple omega 3-6-9 to mice led to a reduction in the toxicity of cisplatin. These results indicate that triple omega 3-6-9 provides protection against the toxicity that is produced by cisplatin in the kidney. One possible explanation for this is that it possesses anti-inflammatory and antioxidant effects.<\/span><\/span><\/p>\n

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