{"id":3948,"date":"2023-10-13T11:03:13","date_gmt":"2023-10-13T11:03:13","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948"},"modified":"2023-10-13T11:03:13","modified_gmt":"2023-10-13T11:03:13","slug":"discussion-the-design-synthesis-and-preliminary-antiproliferative-evaluation-of-new-histone-deacetylase-inhibitors-with-isoxazole-moiety-as-zinc-binding-group","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948","title":{"rendered":"Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The College of Pharmacy discussed the master\u2019s thesis entitled Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group by the student <strong>Ali Mohammed Saeed Abulameer<\/strong> and his supervisor, Assistant Professor <strong>Dr.<\/strong> <strong>Ayad Abed Ali Al-Hamashi, <\/strong>in the Pharmaceutical Chemistry Department.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">Based on the molecular modeling studies, the newly designed isoxazole-based histone deacetylase (HDAC) inhibitors were docked against different isoforms using the Schrodinger modeling suite. Compounds with isoxazole moiety were linked to the cap and linker to give the final compounds that showed virtual bidentate zinc chelation in the HDACs active site, which is important for the inhibition. The organic synthesis of the final compounds began with the protection of 4-aminobenzylalcohol using silyl chloride, followed by amide bond formation with carboxylic acid under mild conditions. Deprotection of silyl was performed under mild conditions using simple stirring with acetyl chloride to give key intermediates, which were then linked to isoxazole by an ether bond or ester bond to afford the final products. The reactions were monitored using thin-layer chromatography to ensure the completion of the reactions and predict the best method for purification using column chromatography.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The final compounds were characterized using infrared spectroscopy and nuclear magnetic resonance spectroscopy. An evaluation of preliminary antiproliferative activities against colon cancer cell lines showed that the compound linked to isoxazole by ether linkage has an antiproliferative activity of low micromolar IC<sub>50<\/sub>, which is comparable to the FDA-approved HDAC inhibitor vorinostat.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_47408\" class=\"cz_grid_p cz_47408\"><div class=\"cz_grid cz_grid_1 clr cz_grid_c2 cz_grid_l2 cz_grid_1_no_title cz_grid_1_mid tac cz_tooltip cz_grid_1_no_title\"><div class=\"cz_grid_item cz_grid_first\"><\/div><div class=\"cz_grid_item \"><div data-title=\"1\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"956\" height=\"451\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"1\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg 956w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2-300x142.jpg 300w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2-768x362.jpg 768w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2-600x283.jpg 600w\" sizes=\"auto, (max-width: 956px) 100vw, 956px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"2\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/2-1.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"500\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/2-1-1200x500.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"2\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the master\u2019s thesis entitled Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":3949,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7],"tags":[],"class_list":["post-3948","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group - College of Pharmacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group - College of Pharmacy\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the master\u2019s thesis entitled Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase ... more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948\" \/>\n<meta property=\"og:site_name\" content=\"College of Pharmacy\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/collegeofpharmacy1\" \/>\n<meta property=\"article:published_time\" content=\"2023-10-13T11:03:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"956\" \/>\n\t<meta property=\"og:image:height\" content=\"451\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"copharm\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"copharm\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#article\",\"isPartOf\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948\"},\"author\":{\"name\":\"copharm\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/person\/85a43e42ae13b942c002c21c7772fd83\"},\"headline\":\"Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group\",\"datePublished\":\"2023-10-13T11:03:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948\"},\"wordCount\":297,\"publisher\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#organization\"},\"image\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#primaryimage\"},\"thumbnailUrl\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg\",\"articleSection\":[\"Activates\",\"dissuasion\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948\",\"url\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948\",\"name\":\"Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group - College of Pharmacy\",\"isPartOf\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#primaryimage\"},\"image\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#primaryimage\"},\"thumbnailUrl\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg\",\"datePublished\":\"2023-10-13T11:03:13+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#primaryimage\",\"url\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg\",\"contentUrl\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg\",\"width\":956,\"height\":451},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#website\",\"url\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/\",\"name\":\"College of Pharmacy\",\"description\":\"University of baghdad\",\"publisher\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#organization\",\"name\":\"University of Baghdad\",\"url\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/05\/pharmacy-logo.png\",\"contentUrl\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/05\/pharmacy-logo.png\",\"width\":200,\"height\":188,\"caption\":\"University of Baghdad\"},\"image\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/collegeofpharmacy1\",\"https:\/\/www.instagram.com\/college_of_pharmacy_uob\/?igsh=NWcwMnFpd2M5bDdt\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/person\/85a43e42ae13b942c002c21c7772fd83\",\"name\":\"copharm\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/f92b31e3166ccc8eb8809e0d2fd33dc624d190730b3e36686c99ffdac172690b?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/f92b31e3166ccc8eb8809e0d2fd33dc624d190730b3e36686c99ffdac172690b?s=96&d=mm&r=g\",\"caption\":\"copharm\"},\"url\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?author=9\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group - College of Pharmacy","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948","og_locale":"en_US","og_type":"article","og_title":"Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group - College of Pharmacy","og_description":"[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the master\u2019s thesis entitled Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase ... more","og_url":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948","og_site_name":"College of Pharmacy","article_publisher":"https:\/\/www.facebook.com\/collegeofpharmacy1","article_published_time":"2023-10-13T11:03:13+00:00","og_image":[{"width":956,"height":451,"url":"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg","type":"image\/jpeg"}],"author":"copharm","twitter_card":"summary_large_image","twitter_misc":{"Written by":"copharm","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#article","isPartOf":{"@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948"},"author":{"name":"copharm","@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/person\/85a43e42ae13b942c002c21c7772fd83"},"headline":"Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group","datePublished":"2023-10-13T11:03:13+00:00","mainEntityOfPage":{"@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948"},"wordCount":297,"publisher":{"@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/#organization"},"image":{"@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#primaryimage"},"thumbnailUrl":"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg","articleSection":["Activates","dissuasion"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948","url":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948","name":"Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group - College of Pharmacy","isPartOf":{"@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/#website"},"primaryImageOfPage":{"@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#primaryimage"},"image":{"@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#primaryimage"},"thumbnailUrl":"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg","datePublished":"2023-10-13T11:03:13+00:00","breadcrumb":{"@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#primaryimage","url":"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg","contentUrl":"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/10\/1-2.jpg","width":956,"height":451},{"@type":"BreadcrumbList","@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=3948#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/en.copharm.uobaghdad.edu.iq\/"},{"@type":"ListItem","position":2,"name":"Discussion \u00a0the Design, Synthesis, and Preliminary Antiproliferative Evaluation of New Histone Deacetylase Inhibitors with Isoxazole Moiety as Zinc-Binding Group"}]},{"@type":"WebSite","@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/#website","url":"https:\/\/en.copharm.uobaghdad.edu.iq\/","name":"College of Pharmacy","description":"University of baghdad","publisher":{"@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/en.copharm.uobaghdad.edu.iq\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/#organization","name":"University of Baghdad","url":"https:\/\/en.copharm.uobaghdad.edu.iq\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/logo\/image\/","url":"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/05\/pharmacy-logo.png","contentUrl":"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/05\/pharmacy-logo.png","width":200,"height":188,"caption":"University of Baghdad"},"image":{"@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/collegeofpharmacy1","https:\/\/www.instagram.com\/college_of_pharmacy_uob\/?igsh=NWcwMnFpd2M5bDdt"]},{"@type":"Person","@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/person\/85a43e42ae13b942c002c21c7772fd83","name":"copharm","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/f92b31e3166ccc8eb8809e0d2fd33dc624d190730b3e36686c99ffdac172690b?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/f92b31e3166ccc8eb8809e0d2fd33dc624d190730b3e36686c99ffdac172690b?s=96&d=mm&r=g","caption":"copharm"},"url":"https:\/\/en.copharm.uobaghdad.edu.iq\/?author=9"}]}},"modified_by":"copharm","_links":{"self":[{"href":"https:\/\/en.copharm.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/3948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/en.copharm.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/en.copharm.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/en.copharm.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/en.copharm.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3948"}],"version-history":[{"count":0,"href":"https:\/\/en.copharm.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/posts\/3948\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/en.copharm.uobaghdad.edu.iq\/index.php?rest_route=\/wp\/v2\/media\/3949"}],"wp:attachment":[{"href":"https:\/\/en.copharm.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/en.copharm.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/en.copharm.uobaghdad.edu.iq\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}