{"id":4118,"date":"2023-11-04T06:53:41","date_gmt":"2023-11-04T06:53:41","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=4118"},"modified":"2023-11-04T06:53:41","modified_gmt":"2023-11-04T06:53:41","slug":"discussion-potential-pharmacogenetic-and-biochemical-markers-to-predict-steroid-responsiveness-in-a-sample-of-iraqi-children-with-idiopathic-nephrotic-syndrome","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=4118","title":{"rendered":"Discussion Potential Pharmacogenetic and Biochemical Markers to Predict Steroid Responsiveness in a Sample of Iraqi Children with Idiopathic Nephrotic Syndrome"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The Faculty of Pharmacy discussed the PhD dissertation entitled \u201cPotential Pharmacogenetic and Biochemical Markers to Predict Steroid Responsiveness in a Sample of Iraqi Children with Idiopathic Nephrotic Syndrome\u201d by Ali Mohammed Abd Alridha and the supervisors, Assistant Professor Dr. Dheyaa Jabbar Kadhim and Dr. Ayad Hussein Alkhazrajy, in the Clinical Pharmacy Department.\u00a0The study aimed to evaluate the potential of uVDBP and uNGAL as non-invasive biomarkers to distinguish steroid-resistant INS (SRNS) from steroid-sensitive INS (SSNS) in Iraqi children. Furthermore, this study investigated the association of the <em>MDR-1<\/em> C1236T and C3435T genotypes and haplotypes with the risk of steroid resistance development in Iraqi INS children.\u00a0A cross-sectional study was conducted to evaluate the urinary biomarkers\u2019 levels in two groups of participants [SSNS (n = 32) and SRNS (n = 31)]. Quantitative analysis of uVDBP and uNGAL levels was undertaken via commercially available ELISA kits. Additionally, children with SRNS and SSNS were genotyped by amplification of the target variants\u2019 sequence using polymerase chain reaction (PCR) and digestion of the amplification products via appropriate endonuclease enzymes capable of detecting restriction fragment length polymorphism (RFLP).\u00a0The results showed that the median uVDBP and mean uNGAL values were higher (p-value&lt;0.001) in the SRNS group than in the SSNS group.\u00a0The study concluded that each of uVDBP and uNGAL was associated with a reliable discriminatory strength to noninvasively distinguish children with SRNS from those with SSNS. Moreover, children who have the <em>MRD-1<\/em> C1236T TT genotype alone or combined with the C3435T TT genotype may be at increased risk of developing SRNS and in need of other therapeutic strategies.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_82457\" class=\"cz_grid_p cz_82457\"><div class=\"cz_grid cz_grid_1 clr cz_grid_c1 cz_grid_l1 cz_grid_1_no_title cz_grid_1_mid tac cz_tooltip cz_grid_1_no_title\"><div class=\"cz_grid_item cz_grid_first\"><\/div><div class=\"cz_grid_item \"><div data-title=\"12\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/11\/12.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"500\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2023\/11\/12-1200x500.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"12\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The Faculty of Pharmacy discussed the PhD dissertation entitled \u201cPotential Pharmacogenetic and Biochemical Markers to Predict Steroid Responsiveness in &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=4118\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":4119,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7],"tags":[],"class_list":["post-4118","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - 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