{"id":5519,"date":"2024-02-29T04:07:22","date_gmt":"2024-02-29T04:07:22","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=5519"},"modified":"2024-02-29T04:08:52","modified_gmt":"2024-02-29T04:08:52","slug":"impact-of-cannabinoid-receptor-1-gene-polymorphism-on-kidney-injury-among-iraqi-non-obese-type-2-diabetes-mellitus-patients","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=5519","title":{"rendered":"Impact of Cannabinoid Receptor-1 Gene Polymorphism on Kidney Injury among Iraqi Non-obese Type 2 Diabetes Mellitus Patients"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The College of Pharmacy discussed the PhD dissertation entitled \u201cImpact of Cannabinoid Receptor-1 Gene Polymorphism on Kidney Injury among Iraqi Non-obese Type 2 Diabetes Mellitus Patients\u201d by Raghda Hisham Khalil and the supervisors, Professor Dr. Eman Saadi Saleh and Consultant Dr. Khalaf Gatea Hussien, at the Clinical Laboratory Sciences Department. The study aimed to estimate the possible association between single nucleotide polymorphisms of cannabinoid receptor-1, evaluate serum and urine levels of KIM-1 and nephrin, and study the association of CNR-1 gene polymorphisms with these biomarkers in diabetic patients. This study concluded that certain genetic variations (polymorphisms) like rs1776966256, rs750464422, and rs1243008337 were found to be linked to the development of DN, a kidney disease associated with diabetes. However, another polymorphism, rs1776965150, was not associated with DN. Additionally, the study identified KIM-1 and nephrin as sensitive indicators of early-stage renal damage in DN.Finally, it was observed that rs1776966256 and rs1243008337 polymorphisms did not appear to affect KIM-1 and nephrin levels. However, the rs1776965150 polymorphism might affect the KIM-1 level, and the rs750464422 polymorphism might influence nephrin levels, potentially leading to podocyte destruction in Type 2 diabetes patients.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_11787\" data-position=\"top-right\" class=\"cz_11787 cz_image clr cz_image_no_fx center_on_mobile\"><div class=\"\" ><div class=\"cz_image_in\"><div class=\"cz_main_image\"><img loading=\"lazy\" decoding=\"async\" width=\"1230\" height=\"686\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/1-19.jpg\" class=\"attachment-full\" alt=\"\" title=\"1\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/1-19.jpg 1230w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/1-19-300x167.jpg 300w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/1-19-1024x571.jpg 1024w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/1-19-768x428.jpg 768w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/1-19-600x335.jpg 600w\" sizes=\"auto, (max-width: 1230px) 100vw, 1230px\" \/><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_28071\" data-position=\"top-right\" class=\"cz_28071 cz_image clr cz_image_no_fx center_on_mobile\"><div class=\"\" ><div class=\"cz_image_in\"><div class=\"cz_main_image\"><img loading=\"lazy\" decoding=\"async\" width=\"1124\" height=\"1301\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/2-20.jpg\" class=\"attachment-full\" alt=\"\" title=\"2\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/2-20.jpg 1124w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/2-20-259x300.jpg 259w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/2-20-885x1024.jpg 885w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/2-20-768x889.jpg 768w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/02\/2-20-600x694.jpg 600w\" sizes=\"auto, (max-width: 1124px) 100vw, 1124px\" \/><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the PhD dissertation entitled \u201cImpact of Cannabinoid Receptor-1 Gene Polymorphism on Kidney Injury among &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=5519\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":5520,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[3,7],"tags":[],"class_list":["post-5519","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - 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