{"id":6731,"date":"2024-06-07T18:27:08","date_gmt":"2024-06-07T18:27:08","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=6731"},"modified":"2024-06-07T18:27:08","modified_gmt":"2024-06-07T18:27:08","slug":"lasmiditan-nano-emulsion-based-in-situ-gel-intranasal-dosage-form-formulation-characterization-and-in-vivo-study","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=6731","title":{"rendered":"Lasmiditan Nano-emulsion-Based In-Situ Gel Intranasal Dosage Form: Formulation, Characterization, and In-vivo Study"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The College of Pharmacy discussed the PhD dissertation entitled<strong> \u201cLasmiditan Nano-emulsion-Based In-Situ Gel Intranasal Dosage Form: Formulation, Characterization, and In-vivo Study\u201d. submitted by the<\/strong> by the PhD student assistant. Prof. <strong>Saba Abdulhadi Jaber<\/strong><strong> and her supervisor <\/strong><strong>Prof. Dr. Nawal Ayash Rajab, in the Pharmaceutics Department.\u00a0 <\/strong>This study aimed to improve LAS bioavailability via formulation as nano-emulsion-based in situ gel (NEIG) given intranasally to achieve rapid onset with a higher extent of drug absorption (higher bioavailability). Thirty-eight LAS nano-emulsions (NEs) were prepared using the spontaneous emulsi\ufb01cation method with ultrasonication. \u00a0Visual Characterization, Thermodynamic stability study, globule size, polydispersity index (PDI), drug content as well and in vitro release, all were\u00a0measured to predict the optimum formulations that pass through the ex vivo studies. <strong>F15<\/strong> (NE <strong>a)<\/strong>, and <strong>F31<\/strong>(NE <strong>b)<\/strong> are the only successfully prepared NE formulas that were selected for the incorporation of different percentages of pH-sensitive in situ gelling polymer (Carbopol 934) to prepare NEIGs <strong>1<\/strong>, <strong>2<\/strong>, <strong>3<\/strong>, <strong>4<\/strong>, <strong>5<\/strong>, and <strong>6<\/strong>. The pH, gelation capacity, gel strength, and viscosity were predicted for the prepared NEIGs. The release (<em>in-vitro<\/em>) and the nasal permeation (<em>ex-vivo<\/em>) were determined for NEIG <strong>2<\/strong> and <strong>5<\/strong>, then both were subjected to pharmacokinetics in vivo studies using 18 male rabbits weighing 1.8-2.0 kg. <strong>In conclusion, <\/strong>NEIG <strong>2 <\/strong>and NEIG <strong>5<\/strong> are promising intranasal new formulas with improving bioavailability (rapid T max and higher C max) than the oral dosage form (AQS), although the selected optimum golden formula that will be ready for further clinical study is NEIG<strong> 2<\/strong>.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_98907\" class=\"cz_grid_p cz_98907\"><div class=\"cz_grid cz_grid_1 clr cz_grid_c2 cz_grid_l2 cz_grid_1_no_title cz_grid_1_mid tac cz_tooltip cz_grid_1_no_title\"><div class=\"cz_grid_item cz_grid_first\"><\/div><div class=\"cz_grid_item \"><div data-title=\"Picture1\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/06\/Picture1-2.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"500\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/06\/Picture1-2-1200x500.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"Picture1\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"Picture2\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/06\/Picture2-2.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"500\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/06\/Picture2-2-1200x500.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"Picture2\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"Picture3\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/06\/Picture3-2.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"693\" height=\"500\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/06\/Picture3-2-693x500.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"Picture3\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"Picture4\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/06\/Picture4-1.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"500\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/06\/Picture4-1-1200x500.jpg\" class=\"attachment-codevz_1200_500\" alt=\"\" title=\"Picture4\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the PhD dissertation entitled \u201cLasmiditan Nano-emulsion-Based In-Situ Gel Intranasal Dosage Form: Formulation, Characterization, and &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=6731\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":6732,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7,5],"tags":[],"class_list":["post-6731","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion","category-last-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - 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