{"id":6880,"date":"2024-07-09T23:50:42","date_gmt":"2024-07-09T23:50:42","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=6880"},"modified":"2024-07-09T23:50:42","modified_gmt":"2024-07-09T23:50:42","slug":"phytochemical-investigation-of-mesembryanthemum-cordifolium-l-f-faizoaceae-cultivated-in-iraq-and-assessment-of-it-is-anti-angiogenic-activity","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=6880","title":{"rendered":"Phytochemical investigation of Mesembryanthemum cordifolium l.f. (F:Aizoaceae) cultivated in Iraq\u00a0 and assessment of it is anti-angiogenic activity"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The College of Pharmacy discussed the\u00a0MSc thesis\u00a0entitled \u00a0\u201cPhytochemical investigation of Mesembryanthemum cordifolium l.f. (F:Aizoaceae) cultivated in Iraq\u00a0 and assessment of it is anti-angiogenic activity\u201d by the student Zahraa Jasim Abed and the supervisor, Assistant Professor Dr. Amjed Haseeb Khamees, at the Department of Pharmacognosy and Medicinal Plants . This study is considered the first study for the detection of the components of the Mesembryanthemum cordifolium plant cultivated in Iraq\u00a0 and the assessment of its anti-angiogenic activity (blood vessel formation). This study focuses on the extraction, fractionation, isolation, purification, identification, and quantitative estimation of several biologically significant constituents found in the plant. These constituents belong to four major groups, including alkaloids, lignans, polyphenols, and flavonoids. Plant material was extracted using a Soxhlet apparatus after defatting with n-hexane for 72 hr. and replacement of solvent for three times (each 24 hr.). The crude methanolic extract then was fractionated using solvents of different polarity. The extracts were then subjected to preliminary phytochemical screening, TLC, and HPLC to detect various chemical constituents. Active components were isolated using preparative TLC and characterized using TLC, FTIR, NMR, and LC-MS-MS. Anti-angiogenic activity was assessed by testing different fractions (petroleum ether, chloroform and ethyl acetate) on rat aortic rings.Phytochemical analysis revealed the presence of alkaloids, lignans, polyphenols, and flavonoids in Mesembryanthemum cordifolium. Five compounds were isolated and identified: unknown alkaloids, Pinoresinol, ferulic acid, luteolin, and caffeic acid. In the angiogenesis assay, petroleum ether, chloroform, and ethyl acetate fractions significantly inhibited blood vessel growth compared to the control group, and suramin (positive control). The chloroform fraction exhibited the strongest anti-angiogenic effect. This study, the first study on Mesembryanthemum cordifolium cultivated in Iraq, demonstrates the presence of diverse bioactive compounds and highlights its potential as a source of anti-angiogenic agents. The identification of a novel alkaloid and determine its structure. The strong anti-angiogenic activity of the chloroform fraction suggests its potential for further exploration in the development of anti-angiogenic therapies.Additional research is necessary to discover unidentified chemicals in this plant, examine the levels of alkaloids, flavonoids, phenolic compounds, lignans present in the plant and identify the primary bioactive compounds responsible for the antiangiogenic action of the plant.\u00a0<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_48741\" class=\"cz_grid_p cz_48741\"><div class=\"cz_grid cz_grid_1 clr cz_grid_c2 cz_grid_1_no_title cz_grid_1_mid tac cz_tooltip cz_grid_1_no_title\"><div class=\"cz_grid_item cz_grid_first\"><\/div><div class=\"cz_grid_item \"><div data-title=\"3\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/07\/3-1.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/07\/3-1-600x600.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"3\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/07\/3-1-600x600.jpg 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/07\/3-1-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"4\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/07\/4-1.jpg\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/07\/4-1-600x600.jpg\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"4\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/07\/4-1-600x600.jpg 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/07\/4-1-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the\u00a0MSc thesis\u00a0entitled \u00a0\u201cPhytochemical investigation of Mesembryanthemum cordifolium l.f. (F:Aizoaceae) cultivated in Iraq\u00a0 and assessment &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=6880\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":6881,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7,5],"tags":[],"class_list":["post-6880","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion","category-last-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Phytochemical investigation of Mesembryanthemum cordifolium l.f. (F:Aizoaceae) cultivated in Iraq\u00a0 and assessment of it is anti-angiogenic activity - College of Pharmacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=6880\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Phytochemical investigation of Mesembryanthemum cordifolium l.f. (F:Aizoaceae) cultivated in Iraq\u00a0 and assessment of it is anti-angiogenic activity - College of Pharmacy\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the\u00a0MSc thesis\u00a0entitled \u00a0\u201cPhytochemical investigation of Mesembryanthemum cordifolium l.f. (F:Aizoaceae) cultivated in Iraq\u00a0 and assessment ... more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=6880\" \/>\n<meta property=\"og:site_name\" content=\"College of Pharmacy\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/collegeofpharmacy1\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-09T23:50:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2024\/07\/3-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"853\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"copharm\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"copharm\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=6880#article\",\"isPartOf\":{\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=6880\"},\"author\":{\"name\":\"copharm\",\"@id\":\"https:\/\/en.copharm.uobaghdad.edu.iq\/#\/schema\/person\/85a43e42ae13b942c002c21c7772fd83\"},\"headline\":\"Phytochemical investigation of Mesembryanthemum cordifolium l.f. 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