{"id":7174,"date":"2024-09-21T16:52:37","date_gmt":"2024-09-21T16:52:37","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=7174"},"modified":"2024-09-21T16:52:37","modified_gmt":"2024-09-21T16:52:37","slug":"synthesis-characterization-of-new-isatin-thiazole-derivatives-with-preliminary-biological-activity","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=7174","title":{"rendered":"Synthesis, Characterization of New Isatin \u2013Thiazole Derivatives with Preliminary Biological Activity"},"content":{"rendered":"

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The College of Pharmacy discussed the MSc thesis entitled \u201cSynthesis, Characterization of New Isatin-Thiazole Derivatives with Preliminary Biological Activity<\/strong>\u201d by the student Marwa Hashim Mohammad Hashim <\/strong>and the supervisor, Assistant Professor. May Mohammad Jawad<\/strong>, at the Pharmaceutical Chemistry Department. The study aimed<\/strong> to synthesize different Schiff bases of 2-aminothiazole and N<\/em>-propargylated Mannich bases of isatin and predict their antimicrobial activity (AM1-AM5<\/strong>). Also, synthesize different N<\/em>-Mannich bases of isatin conjugated to thiazole ring via imine linkage and predict their antimicrobial activity (MT1-MT5).<\/strong> The study included<\/strong> several Schiff and Mannich bases formed from isatin that were synthesized. Acetylenic Mannich bases (IIa-e<\/strong>) were prepared by a reaction of isatin with propargyl bromide and different secondary amines (morpholine, piperidine, pyrrolidine, dimethylamine, and diphenylamine) separately, and cuprous chloride (CuCl) was used as a catalyst. These Mannich bases were treated with 2-aminothiazole to obtain the desired final compounds (AM1-AM5<\/strong>). The FT-IR and 1H-NMR spectral data were used to characterize these synthesized compounds. Another number of Schiff and Mannich bases obtained from isatin were synthesized. First, Mannich bases (2a-e<\/strong>) were prepared by a reaction of isatin with formaldehyde and different secondary amines (morpholine, piperidine, pyrrolidine, diethylamine, and N-methylaniline) separately. These Mannich bases were also treated with 2-aminothiazole to obtain the desired final compounds (MT1-MT5<\/strong>). The antimicrobial activity of each of these derivatives was examined against two species of Gram+ve bacteria (Staphylococcus aureus<\/em> and Bacillus licheniformis<\/em>), two species of Gram-ve bacteria (Escherichia coli <\/em>and Acinetobacter baumannii<\/em>), and one species of fungus species (Candida albicans<\/em>). The study concluded<\/strong> that most of the compounds were found to exhibit significant antimicrobial activity, and the most active are compounds AM1, MT5.<\/strong> The study recommended<\/strong> Screening for anti-inflammatory effects of different final Schiff base compounds. We are also testing the anticancer activity of acetylenic Mannich and Schiff bases.<\/span><\/p>\n

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[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the MSc thesis entitled \u201cSynthesis, Characterization of New Isatin-Thiazole Derivatives with Preliminary Biological Activity\u201d … <\/i>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":7175,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7,5],"tags":[],"class_list":["post-7174","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion","category-last-news"],"yoast_head":"\nSynthesis, Characterization of New Isatin \u2013Thiazole Derivatives with Preliminary Biological Activity - College of Pharmacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=7174\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Synthesis, Characterization of New Isatin \u2013Thiazole Derivatives with Preliminary Biological Activity - 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