{"id":9774,"date":"2025-03-10T05:51:01","date_gmt":"2025-03-10T05:51:01","guid":{"rendered":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=9774"},"modified":"2025-03-10T05:51:01","modified_gmt":"2025-03-10T05:51:01","slug":"synthesis-characterization-and-preliminary-antimicrobial-activity-evaluation-of-new-amino-acids-derivatives-of-sulfanilamide","status":"publish","type":"post","link":"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=9774","title":{"rendered":"Synthesis, Characterization and Preliminary Antimicrobial Activity Evaluation of New Amino acids Derivatives of Sulfanilamide"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 19px;\">The College of Pharmacy discussed the MSc thesis entitled \u201cSynthesis, Characterization and Preliminary Antimicrobial Activity Evaluation of New Amino acids Derivatives of Sulfanilamide\u201d by the student Haider Mohsen Naeem and his supervisor, Lecturer Dr. Zainab Abdelhadi Dakhel, at the Pharmaceutical Chemistry Department. The study aimed to synthesize a new series of amino acids, glycine and L- Phenylalanine, derivatives of sulfanilamide with an <em>in-vitro <\/em>evaluation of their antimicrobial activity. The study included the molecular docking of the final compounds targeting dihydropteroate synthetase enzyme, chemical synthesis and an <em>in-vitro<\/em> antimicrobial assessment against different bacteria, <em>Staphylococcus aureus<\/em> and <em>Streptococcus pneumoniae<\/em>, <em>Pseudomonas aeruginosa<\/em>, and <em>Escherichia coli<\/em> and one fungus, <em>Candida albicans<\/em> through minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC). Minimum fungicidal concentration (MFC), and zone of inhibition values determination. The results showed that the compounds P3, P1, P2, and G6 obtained the higher docking scores(-6.5, -6.494, -6.466, and -6.295 Kcal\/mol, respectively) while the standard precursors (sulfamethoxazole and sulfadiazine) obtained docking scores (-5.895 and -5712 Kcal\/mol respectively), while the compounds G5, G6, and P4 scored the highest antifungal activity with zone of inhibition values (21, 21, \u00a0and 20 mm respectively) the compounds G3, G4, P3, and P4 had the highest antibacterial inhibitory effect with zone of inhibition values (23, 24, 23,\u00a0 and 23 mm respectively). The study recommended the assessment of other biological activities with synthesis of new derivatives.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"cz_61450\" class=\"cz_grid_p cz_61450\"><div class=\"cz_grid cz_grid_1 clr cz_grid_c3 cz_grid_1_no_title cz_grid_1_mid tac cz_tooltip cz_grid_1_no_title\"><div class=\"cz_grid_item cz_grid_first\"><\/div><div class=\"cz_grid_item \"><div data-title=\"Picture1\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture1-1.png\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture1-1-600x600.png\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"Picture1\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture1-1-600x600.png 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture1-1-150x150.png 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"Picture2\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture2.png\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture2-600x600.png\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"Picture2\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture2-600x600.png 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture2-150x150.png 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><div class=\"cz_grid_item \"><div data-title=\"Picture3\"><a class=\"cz_grid_link \" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture3.png\" data-xtra-lightbox><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture3-600x600.png\" class=\"attachment-codevz_600_600\" alt=\"\" title=\"Picture3\" srcset=\"https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture3-600x600.png 600w, https:\/\/en.copharm.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/80\/2025\/03\/Picture3-150x150.png 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><div class=\"cz_grid_details\"><i class=\"fa fa-search cz_grid_icon\"><\/i><\/div><\/a><\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] The College of Pharmacy discussed the MSc thesis entitled \u201cSynthesis, Characterization and Preliminary Antimicrobial Activity Evaluation of New Amino &#8230; <a class=\"cz_readmore\" href=\"https:\/\/en.copharm.uobaghdad.edu.iq\/?p=9774\"><i class=\"fa czico-132-arrows-8\" aria-hidden=\"true\"><\/i><span>more<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":9775,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3,7,5],"tags":[],"class_list":["post-9774","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-dissuasion","category-last-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - 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