The researchers, Lecturer Mahmood Kahtan Ismail and Prof. Dr. Shihab Hattab Mutlag at the Pharmacology and Toxicology Department, have published the results of their scientific research in one of the famous international journals ranked within the first quartile (Q1), known for its high impact factor and distinguished scientific reputation.
The study focused on investigating the protective effects of Conocarpus erectus leaf extracts against hypothyroidism induced by Propylthiouracil in rats. Histological analysis in extract-treated hypothyroid rats revealed improved follicular regeneration and enhanced neovascularization. In addition, Western blotting showed increased Bcl-2 and decreased cleaved caspase-3 and caspase-8 levels, while RT-qPCR demonstrated significant downregulation of proinflammatory and apoptotic genes, including TNF, NLRP3, TRAIL, and NF-κB. These findings represent a valuable scientific contribution that indicates the potential of using Conocarpus erectus extracts as a complementary therapy against endocrine diseases, including thyroid disorders.
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