The College of Pharmacy discussed the PhD dissertation entitled “Tizanidine –Loaded Cubosomes for Transdermal Delivery: preparation, In-vitro and In-vivo Evaluation” by the student Milad Jawad Hasan and her supervisor, Professor Dr. Nawal Ayash Rajab in the Pharmaceutics Department.
The study aimed to develop advanced cubosomal systems for the transdermal delivery of tizanidine to enhance its therapeutic efficacy and overcome the limitations associated with oral administration and first-pass hepatic metabolism.
The study included the preparation and characterization of tizanidine-loaded cubosomes using different types of lipids, investigation of their physicochemical properties to assess their efficiency and stability, incorporation of the prepared cubosomes into Carbopol gels suitable for topical application, in vitro evaluation of drug release to determine the release pattern and rate, ex vivo assessment of drug permeation through the skin, and in vivo evaluation of the pharmacological effect using appropriate animal models.
The study concluded that the optimized cubosomal gel formulation exhibited stable physicochemical properties, controlled drug release, and a significant improvement in skin permeation and bioavailability compared to oral administration indicating its potential as a promising alternative for the transdermal delivery of tizanidine.
The study recommended performing future research on the long-term stability of the prepared formulation, expanding pharmacokinetic and clinical studies, investigating the effect of using stabilizers or other supporting systems to improve drug retention, and enhancing therapeutic performance.
