Dr. Sarmed H. Kathem Alkhateeb

Associate Professor
Dean of the College of Pharmacy
Pharmacology and Toxicology Department

Academic Achievements

  • B.Sc. Pharmacy (1998 Honor degree), College of Pharmacy, University of Baghdad
  • M.Sc. Pharmacology and Toxicology (2004), College of Pharmacy, University of Baghdad
  • Ph.D. Pharmacology and Toxicology (2013), College of Pharmacy, University of Baghdad and University of Toledo
  • Postdoctorate (2014), Chapman University and University of California Irvine
  • Research Visiting Scholar (2016), Chapman University

Leaderships and Professional positions

  • Dean of The College of Pharmacy, University of Baghdad
  • Chairman of Deans of Iraqi Pharmacy Colleges Committee
  • Chairman of Committee of Development the curriculum of Iraqi Pharmacy Colleges
  • Member of Iraqi Pharmacist Syndicate
  • Member of the ASPET (American Society of Pharmacology and Experimental Therapeutics)
  • Member of BPS (British Pharmacological Society)
  • Member of the Ministerial committee of the National Standardized Examinations of Pharmacy Colleges
  • Member of NITAG (Iraqi- National Immunization Technical Advisory Group)
  • Editor-in-Chief of the Iraqi Journal of Pharmaceutical Sciences
Awards
  • Outstanding Young Scientist awards (2016), from ASPET at The EB 2016 Conference, San Diego
  • Two National Patents (2023) 

 

Biography

     Dr Sarmed Kathem received his B.Sc. degree in Pharmacy from University of Baghdad in 1998 with honor degree (top 10 graduates). He worked in Ibn-Alnafees Hospital as a clinical pharmacist. Later, he transferred his career to the academic field. Sarmed worked in the University of Baghdad College of Pharmacy as a teaching assistant (1999) then he received M.Sc. in pharmacology (2004) followed by Ph.D. in pharmacology (2012) from the University of Baghdad College of Pharmacy in joint with the college of Pharmacy University of Toledo under the supervision of Dr Surya Nauli. He appointed as a tenured faculty in the University of Baghdad College of Pharmacy from 2005 till now. Sarmed enrolled in postdoctoral research (2014-2016) at Chapman University and University of California, Irvine under Dr Surya Nauli mentorship. He also joined Chapman University School of Pharmacy as research visiting scholar (2016). Sarmed is a member of Dr Nauli’s Primary Cilia group. Later Sarmed resumed his academic career at the college of Pharmacy University of Baghdad, he is active faculty member at the Pharmacology and Toxicology department. He is teaching various Pharmacology and Toxicology courses for the undergraduate and postgraduate students. Later he recruited as the Dean of the college of Pharmacy since 2019.

Research Summary and interest

      Dr. Kathem enrolled in the primary cilia research group with Dr. Surya Nauli in the University of Toledo in 2012, then he also re-joined with Dr. Nauli to pursue his research in Chapman University and University of California Irvine in 2014. Dr. Kathem’s research focused on the molecular components of primary cilia mechanosensory and chemosensory functions in endothelial and renal epithelial cells. The research focused on the role primary cilia in coordinating the dopaminergic, Ca and NO signaling of the cells in polycystic kidney disease. That research includes in vitro models, animal models and clinical studies. In addition, the role of primary cilia in planar cell polarity also explored in relation to polycystic kidney disease (PKD). The research continued looking for more signaling pathways regulated by primary cilia in endothelial and renal epithelial cells, these signaling pathways expected to have potential pharmacological impact on PKD.
Dr. Kathem worked with Chapman’s cilia research group led by Dr. Surya Nauli, their experimental and clinical research intending: 1) to increase our knowledge on the role of primary cilia in disease, specially the cardiovascular component of PKD like hypertension; 2) to find cilia-related molecular targets to be utilized for therapeutic purposes. Their research on primary cilia aiming to translate the experimental findings into clinical practice in an attempt to shed the light on the way to pharmacologically rescue primary cilia function or what is called ciliotherapy.
Dr Kathem is also interested in the research related to inflammation at the molecular level. He conducted studies exploring the molecular pathways of the inflammation and potential to find molecular targets that could have promising therapeutic actions to counteract inflammatory events. He conducted studies investigating the roles of natural compounds in ameliorating inflammatory pathways and protecting vital organs from injury. Dr Kathem earned two National Patents for finding natural compounds that counteract inflammatory events in kidney that have potential promising therapeutic activity.
In addition, Dr Kathem interested in pharmacy education, he involved in studies that aimed to develop Iraqi Pharmacy colleges in terms of curriculum and education.

Publications 

  1. Yasameen S Mahmood, Sarmed H Kathem. Protective effect of citronellol in rhabdomyolysis- induced acute kidney injury in mice. J Med Life 2023,16(7): 1057
  2. Saja M Shareef, Sarmed H Kathem. Gentiopicroside ameliorates Lipopolysaccharide- induced acute kidney injury by inhibiting TLR4/NF‐κB signaling in mice models. J Pharma Neg Res 2022, 13(4):135-145
  3. Sarmed H Kathem, Waleed K Abdulsahib, Munaf H Zalzala. Berbamine and thymoquinone exert protective effects against immune-mediated liver injury via NF-κB dependent pathway, Vet. Sci 2022, 9: 960981
  4. Saja M Shareef, Sarmed H Kathem. Gentiopicroside ameliorates acute inflammatory kidney injury in a mouse model induced by LPS through hampering NF‐κB, AP‐1 and IRF3 pathways. The FASEB J. 2022, 36
  5. Samah M Redha, Sarmed H Kathem. Citronellol exerts lung protective and anti‐inflammatory effects through hampering NF‐κB in lipopolysaccharide‐induced acute lung injury in mice. The FASEB J. 2022, 36
  6. Kawther Khalid Ahmed, Ali Azeez Al-Jumaili, Salema Sultan Salman, Sarmed H Kathem. The Students’ Experience of Hybrid-Education Model at The University of Baghdad College of Pharmacy: Lessons and Future Directions. Iraqi J of Pharmaceutical Sc, 2021,30(2):269-277
  7. Ban Walid Abbas, Sarmed H Kathem. Carvone Attenuates Irinotecan-Induced Intestinal Mucositis and Diarrhea in Mice. Iraqi J of Pharmaceutical Sc, 2021,30(2):58-63
  8. Halla A Ahmad, Sarmed H Kathem. Thymoquinone Attenuates Immune Mediated Liver Injury Induced by Concanavalin A in Mice. Iraqi J of Pharmaceutical Sc, 2021,30(2):50-57
  9. Sarmed H. Kathem, Ali Azeez Al-Jumaili, Malak Noor Aldeen, Noor Najah, Dema Ali Khalid. Measuring Depression and Anxiety Prevalence among Iraqi Healthcare College Students Using Hospital Anxiety and Depression Scale. Pharmacy Practice, 2021,19(2):2303
  10. Kawther Khalid Ahmed, Salema Sultan Salman, Shahad Wisam Alkaisy, Sarmed H. Kathem. Sudden Transition of Pharmacy Education from Traditional to Distance Learning in the Era of COVID-19: Action Steps of a Leading Pharmacy School in Iraq. Iraqi J of Pharmaceutical Sc, 2020,29(2):271-278.
  11. Shahad A. Saad, Sarmed H. Kathem. Evaluation of the Possible Immuno-Protective Effect of Nigella Sativa Seed Oil on Cyclophosphamide- Induced Myelosuppression in Mice. Iraqi J of Pharmaceutical Sc, 2020,29(1):253-259.
  12. Shahad A. Saad, Sarmed H. Kathem. Nigella Sativa Seed Oil Effectively Attenuates Cyclophosphamide-Induced Myelosuppression in Mice. The FASEB J, 2020,34(S1):1-3.
  13. Ahmed F. Al-Talkani, Sarmed H. Kathem. Prevalence of UGT1A1*93 and ABCC5 Polymorphisms in Cancer Patients Receiving Irinotecan-Based Chemotherapy at Al-Najaf Al-Ashraf. Iraqi J of Pharmaceutical Sc, 2019,28(2):24-29.
  14. Sarmed H Kathem, Aliaa AS Abdul Jabbar, Ahmed H Ataimish, Munaf H zalzala. Ethylacetate fractional extract of Mentha spicata attenuates irinotecan-induced mucositis in mice. The FASEB J, 2019,33(1 Supp):4-816.4
  15. Aliaa AS. Abdul Jabbar, Sarmed H. Kathem. The Protective Effect of Mentha spicata Ethanolic Extract on Irinotecan-Induced Mucositis in Mice. Iraqi J of Pharmaceutical Sc, 2019,28(1):37-43.
  16. Rajasekharreddy Pala, Ashraf M Mohieldin, Rinzhin T Sherpa, Sarmed H Kathem, Kiumars Shamloo, Zhongyue Luan, Jing Zhou, Jian-Guo Zheng, Amir Ahsan, Surya M Nauli. Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles. ACS Nano, 2019,13(3):3555–3572.
  17. Wrood s. Al-khfajy, Sarmed H. Kathem, Amani Anees Aboddy, Suhad Faisal Hatem, Munaf h. Zalzala, Inam Sameh Arif. Farnesoid X Receptor is an Exciting New Perspective Target For Treatment Of Diverse Pathological Disorders: Review. J pharm sci & res 2018,10(9):2292.
  18. Sarmed H. Kathem. Flow Generates Delayed Calcium Current From Extracellular Source In Renal Epithelial Cells in vitro. Drug Invention Today 2019,12(1):63-66.
  19. Sarmed H. Kathem. High GSK3β expression in Pkd1 cells. Drug Invention Today 2019,12(1):57-59.
  20. Rajasekharreddy Pala R, Ashraf Mohieldin, Kiumars Shamloo, Rinzhin Sherpa, Sarmed Kathem, Jing Zhou, Zhongyue Luan, Jian-Guo Zheng, Amir Ahsan, Surya Nauli. Personalized Nanotherapy by Specifically Targeting Cell Organelles To Improve Vascular Hypertension. Nano Letters 2018,19(2):904-914.
  21. Sarmed H. Kathem, Flow-Induced Calcium Signal Initiated in the Cilioplasm and Propagated to Cytosol. J Phys Pharm Adv 2016, 6(10): 930-937.
  22. Sarmed H. Kathem, Surya M. Nauli. Mechanosensory function of Cav1.2 calcium channel in renal primary cilia. The FASEB J 2016 ;30 (Supp 1):1188.3-1188.3.
  23. Sarmed H. Kathem, Wissam A. AbouAlaiwi, Xiaolin Zi, Surya M. Nauli. Capillary Endothelia from Two ADPKD Patients are Polyploidy. Ann Clin Cytol Pathol 2016 2(2): 1022.
  24. Waleed K. Abdulsahib, Adeeb Al-Zubaidy, Hayder B. Sahib, Sarmed H. Kathem. Tolaerable ocular hypotensive effect of topically applied sildenafil in ocular normotensive and betamethasone-induced hypertensive rabbits. J. Pharm. Sci. Rev. Res. 2015; 35(1), 96:102.
  25. Kimberly F. Atkinson, Sarmed H. Kathem, Xingjian Jin, Brian S. Muntean, Wissam A. Abou-Alaiwi, Andromeda M. Nauli and Surya M. Nauli . Dopaminergic signaling within the primary cilia in the renovascular system. Front Physiol. 2015 16;6:103.
  26. Surya M. Nauli, Kimberly F. Atkinson, Sarmed H. Kathem. The cell’s antenna. International Innovation 2015; 170:94-96
  27. Sarmed H. Kathem, Ashraf M. Mohieldin, Shakila Abdul-Majeed, Sajida H. Ismail, Qaiss H. Altaei, Ibrahim K. Alshimmari, Mohanned M. Alsaidi, Hussein Khammas, Andromeda M. Nauli, Bina Joe, Albert C. Ong, Surya M. Nauli. Ciliotherapy: a novel intervention in polycystic kidney disease. J Geriatr Cardiol 2014; 11: 111.
  28. Viralkumar S. Upadhyay, Brian S. Muntean, Sarmed H. Kathem, Jangyoun J. Hwang, Wissam A. AbouAlaiwi and Surya M. Nauli. Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells. Physiol. 2014, 5:72.
  29. Sarmed H. Kathem , Ashraf M. Mohieldin , Surya M. Nauli. The Roles of Primary cilia in Polycystic Kidney Disease. AIMS Molecular Science 2013, 1: 27-46.
  30. Sarmed H. Kathem, Ismail S. H. Effect of Fenoldopam on Cytosolic Nitric Oxide Production in Pkd1 Isolated Femoral Arteries in Response to Fluid Shear Stress Ex Vivo. J Phys Pharm Adv 2013, 3(4): 121-126.
  31. Sarmed H. Kathem, Dawser Ismail, Sajida Ismail, Khalid Hussain. Effects of non-steroidal antiinflammatory drugs on the glycemic state and inflammatory marker in poorly controlled type II DM patients. Al-Mustansiriyah Journal for Pharmaceutical Sciences. 2006;3:46-51.

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