The College of Pharmacy discussed the PhD dissertation entitled “Synthesis, Docking Study & preliminary cytotoxicity evaluation of New thiosemicarbazides, Schiff’s bases & Oxadiazole derivatives from 4’-hydroxy(1-1’-biphenyl)-4carboxylic acid” by the student Wurood Shihab Ahmed and the supervisor, Professor Dr. Ammar Abdulrazaq Mahmoud at the pharmaceutical chemistry Department.The study aimed to Synthesize new anti-cancer compounds that act as epidermal growth factor receptor (EGFR) allosteric site inhibitors.The study included the design and synthesis of 23 compounds derived from 4′-Hydroxy (1-1′-biphenyl)-4-carboxylic acid, The final compounds were evaluated in vitro against four human cancer cell lines. Such new compounds were characterized by spectroscopic techniques: infrared (IR) spectroscopy, proton nuclear magnetic resonance (1HNMR), Carbon-13 nuclear magnetic resonance (13CNMR), and electrospray ionization mass spectroscopy (ESI-MS). A molecular docking study for the synthesized compounds was performed, against epidermal growth factor receptor kinase (EGFR kinase). The results showed that some compounds have high potency and selectivity against several cancer cell lines. The study recommended the investigation of the kinetics and stability of final compounds in biological fluids, an in vitro assessment of the final compounds for absorption, distribution, metabolism, excretion, and toxicity (ADMET analysis), and comparing the results with the in-silico findings, and an in vivo study to verify the final compounds by conducting experiments on laboratory animals.
