The College of Pharmacy discussed the PhD dissertation entitled “Synthesis, Docking Study, and Preliminary Cytotoxicity Evaluation of New 4-(tert-butyl)-3-methoxybenzoic Acid Derivatives” by the student Imad Muneeb Malik and the supervisor, Professor Dr. Ammar Abdulrazaq Mahmoud at the Pharmaceutical Chemistry Department. The study aimed to synthesize new anti-cancer compounds that act as EGFR allosteric site inhibitors. The study included the design and synthesis of 20 compounds derived from 4-(tert-butyl)-3-methoxybenzoic acid derivatives. The final compounds were evaluated in vitro against four human cancer cell lines. These compounds were characterized by spectroscopic techniques: ART-FTIR, 1HNMR, 13CNMR, and HRMS. A molecular docking study for the synthesized titled compounds was performed against Epidermal Growth Factor Receptor Kinase (EGFR kinase). The results showed that some compounds have high potency and selectivity against several cancer cell lines. The study recommended to investigate the kinetics and stability of final compounds in biological fluids, an in vitro assessment of the final compounds for ADMET analysis and compare the results with the in-silico findings, and in vivo study for the investigation of the final compounds in animal’s experiments.
