The College of Pharmacy discussed the MSc thesis entitled “Molecular Docking, Synthesis and Preliminary Antimicrobial Evaluation of New Fenamate-Isatin Hybrids” by the student Lubna Layth Taha and her supervisor, Assistant Professor May Mohammed Jawad, at the Pharmaceutical Chemistry Department.
The study aimed to synthesize and characterize of new Fenamates-isatin compounds, followed by in vitro evaluation of their antimicrobial activity against different bacterial strains (Gram-positive and Gram-negative) as well as one fungus.
The study included molecular docking, chemical synthesis and in vitro evaluation of the antimicrobial activity of the final compounds against (Bacillus subtilis, Streptococcus pneumoniae, Staphylococcus aureus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans) utilizing MIC, MBC, and IZ determination.
The results showed that all of the synthesized compounds exhibited significant antibacterial and antifungal activities against the tested microbes, with hybrid 7 showing the greatest activity among the rest, with an MIC 64 μg/mL against 4 of the tested bacteria.
The study recommended in vitro assessment of additional biological properties, including anti-inflammatory, anticancer, antidiabetic, and anticonvulsant effects. Also, the design and synthesis of further derivatives utilizing different isatin analogues or other fenamic acids.
