The College of Pharmacy discussed the Master’s thesis entitled “Synthesis and Antimicrobial Activity of New Etodolac Derivatives”, submitted by the student Sarah Sattar Mohammed and her supervisor Assistant Professor Dr. Muthanna Saadi Farhan in the Pharmaceutical Chemistry Department.
The study aimed to synthesize and characterize new derivatives of Etodolac, followed by in-vitro evaluation of their antimicrobial activity against different bacterial strains (Gram-positive and Gram-negative) as well as one fungal strain.
The study involved the chemical synthesis and in-vitro evaluation of the antimicrobial activity of the final compounds against Bacillus subtilis, Streptococcus pneumoniae, Staphylococcus aureus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans, using Minimum Inhibitory Concentration (MIC) determination and Inhibition Zone (IZ) measurement.
The results revealed that all synthesized compounds demonstrated notable activity against the tested microorganisms. Among them, the hybrid compound D2 exhibited the strongest activity, with a minimum inhibitory concentration (MIC) of 64 μg/mL against Staphylococcus aureus.
The study recommended the synthesis of further derivatives and the expansion of biological investigations in-vitro (such as antioxidant and anticancer activity evaluation) as well as in-vivo, in order to assess the multifunctional activity of the prepared compounds.
