The College of Pharmacy discussed the MSc thesis entitled “Formulation and in vitro Evaluation of Meclizine Hydrochloride Mucoadhesive Thermosensitive in Situ Nasal Gel” by the student Kareem Khudhair Obayes and the supervisor, Assistant Professor Lena Murad Thomas, a faculty member at the Pharmaceutics Department. The study aimed to formulate and evaluate an in situ thermally responsive nasal gel for meclizine hydrochloride with the potential to increase nasal residence time, control drug release rate, and enhance permeability. The study included the preparation of formulations using the cold method and using different concentrations of poloxamers and adhesion polymers to study the effects of various factors, including determining the temperature of gel formation, gel appearance, pH, drug content, gel strength, gel spreadability, viscosity, and release. The results showed the feasibility of formulating meclizine hydrochloride in the form of a thermally sensitive in situ gel on site as an effective drug dosage form used in cases of nausea and vomiting.The study recommended the possibility of preparing meclizine hydrochloride as a thermo-sensitive nasal in situ gel using the method as an easy and successful alternative method for oral administration or other methods.
