The College of Pharmacy discussed the MSc thesis entitled “Evaluationof the Possible Protective Effect of Citronellol Against Folic Acid-Induced Acute Kidney Injury in Mice” by the student Meera Ziyad Jamal and the supervisor, Professor Dr. Sarmed H. Kathem Alkhateeb, at the Pharmacology and Toxicology Department. The study aimed to evaluate Citronellol’s renal protective, anti-inflammatory, and anti-apoptosis effects in folic (FA)-induced acute kidney injury (AKI) in mice model. The study included forty mice who were divided into four groups, each with ten mice. Group I (Control). Group II (Model): Mice received a single intraperitoneal injection of folic acid (250 mg/kg). Group III and VI (Treatment): Mice received 50 and 100 mg/kg/day of citronellol, respectively, orally for four consecutive days. On day four, mice received a single dose of intraperitoneal injection of folic acid (250 mg/kg). On the sixth day, mice were euthanized 48 hours after folic acid injection, with blood collected retro-orbitally. Evaluations included serum urea, serum creatinine, kidney injury molecule-1 mRNA expression, kidney histopathology, inflammation markers, and apoptosis indicators.The study concluded / the results showed that Citronellol-treated mice exhibited a significant reduction in kidney function markers and kidney injury molecule-1 mRNA levels. It also downregulated inflammatory marker gene expression in renal tissue as well as decreased apoptotic markers. The study recommended investigation of the protective effect of citronellol in animal models of AKI induced by various drugs or toxins. Evaluation of its impact on the chronic kidney disease caused by FA, as well as its potential protective effects on other tissues such as the liver and heart. Additionally, the study emphasized the need to investigate the role of the NLRP3inflammasome in the inflammatory pathways and to assess different dosage levels to determine its precise dose-response relationship.
