The College of Pharmacy discussed the MSc thesis entitled “Preparation and Evaluation of zaltoprofen Bilosomes Using Box-Behnken Design as Transdermal Drug Delivery System” by the student Aymen Sami Hameed and his supervisor, Assistant Professor Dr. Fatima Jalal Jawad, at the Pharmaceutics Department. The aim of this study is the development and optimization of zaltoprofen-loaded bilosomes for transdermal application utilizing a Box-Behnken design to enhance permeability and prolong the release of zaltoprofen. The bilosomes will be formulated with various materials, including cholesterol, non-ionic surfactants, and bile salts in varying concentrations. The bilosomes may increasing patient compliance by reducing dosing frequency. This study developed and optimized zaltoprofen-loaded bilosomes for enhanced transdermal delivery using the Box-Behnken design. Bilosomes, formulated with Span 60, Tween 60, cholesterol, and sodium deoxycholate, were prepared via probe sonication, achieving high entrapment efficiency (89.38%), small vesicle size (227.25 nm), and stable zeta potential (-29.84 mV). In vitro release showed sustained drug release over 8 hours, following Korsmeyer-Peppas kinetics. Permeation studies using Franz diffusion cells revealed a 45.09-fold increase in steady-state flux compared to the zaltoprofen dispersion. FTIR confirmed drug compatibility, while TEM and SEM verified spherical, well-distributed vesicles. Stability studies demonstrated structural integrity over 90 days at 4°C and 25°C.These results highlight bilosomes as a promising nanocarrier for enhancing zaltoprofen skin permeability, offering a patient-friendly alternative to oral NSAIDs.
