The Faculty of Pharmacy discussed the PhD dissertation tagged” Synthesis, Docking Studies, and Preliminary Cytotoxic Evaluation of New Tolfenamic Acid Derivatives” by Abbas Abdulridha Mehihi and his supervisor, Professor Dr. Ammar A. Razzak Mahmood in the Department of Pharmaceutical Chemistry. The dissertation aimed to design and synthesize a new series of the parent, tolfenamic acid, derivatives and evaluate them in vitro for cytotoxic effects against cancer cell lines. The dissertation included the method of synthesis and characterization of final compounds using spectroscopic techniques used to validate the target molecules, including FT-IR, 1HNMR, 13CNMR, and MS (ESI). Docking studies were performed to determine the binding patterns to the potential molecular target VEGFR-2, and compared to an in vitro VEGFR-2 tyrosine kinase (TK) inhibition assay. The results proved that all of the newly synthesized compounds were cytotoxic against the three different cancer cell lines. And compounds 4B and 7 were found comparable to sorafenib in terms of cytotoxic activity against the Hep G2 hepatocyte carcinoma cell line.The target compounds 4B and 7 might be regarded as promising cytotoxic agents that will be considered in the development of new anticancer agents.
