The Faculty of Pharmacy discussed the high Mister thesis by Hadeel Saeed Hadi and her supervisor, lecturer Dr. Shaymaa Abdulzahra Abbas in the Clinical Laboratory Sciences Department, presented their Master’s degree thesis, “Correlation of Antioxidant Biomarkers With Elements Levels in Blood Sample of Iraqi Breast Cancer Women,” to the Faculty of Pharmacy. The study aimed to evaluate and measure the serum levels of antioxidant biomarkers like GSH, SOD, GR, GSR-PX, and Sulfhydryl group in the four studied groups, Measure the blood levels of trace elements like iron, copper and zinc in the four studied groups and Possible correlation between serum levels of antioxidant biomarkers and trace elements. This study include participants are divided into group 1 include healthy women as control, group 2 include women with benign disease, group 3 include women with metastasized breast cancer and group 4 include women with breast cancer free from metastasis. Taken the samples and measured the levels of trace elements by colorimetric assay, and the levels of antioxidant biomarkers by ELISA assay. This study concluded that: The levels of zinc, copper and iron were significantly reduced in the metastasized breast cancer patients in comparison with other studied groups. Also the levels of GSH-PX , GR, GSH, and sulfhydral groups were significantly reduced in cancer patients in comparison with controls, whereas SOD activities were upregulated in cancer patients in comparison with healthy controls subjected to the current study, which indicates the impact of these markers on the pathogenisis and progression of breast cancer. All antioxidant biomarkers were significantly and directly correlated to each other, except for SOD which correlates inversily to them .The committee recommended to measure the levels of trace elements and antioxidant biomarkers intercellularly in cancerous tissue and correlate these levels with blood levels, also recommended to increase the number of participants to assess the effect of the trace elements’ levels on the antioxidant biomarkers.
