The Faculty of Pharmacy discussed the Master’s Degree thesis, “Evaluating the Protective Effect of Omega-7 Against Acetaminophen Induced Liver Toxicity in Rats ” by Hadeel Ali Hameed and her supervisor, Assist. Prof. Dr. Ali Faris Hassan in the Pharmacology and Toxicology Department. The thesis aimed to evaluate the protective effect of omega-7 against acetaminophen-induced hepatotoxicity in rats by measuring the following biomarkers: serum alanine-aminotransferase, aspartate aminotransferase, alkaline phosphatase, tumor necrosis factor-alpha, and interleukin-10, while hepatic tissue homogenates were used for the estimation of: superoxide dismutase, catalase, glutathione peroxidase, glutathione and malondialdehyde. Furthermore, a histological examination of rats’ liver sections was also performed. The results showed that treatment of rats with omega-7 produced a significant reduction in levels of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase and a significant decline in levels of inflammatory cytokines tumor necrosis factor-alpha and interleukin-10 compared to acetaminophen group. Moreover, treatment of rats with omega-7 showed significant elevations in the levels of superoxide dismutase, catalase, and reduced glutathione, along with a significant reduction in the level of malondialdehyde compared to the acetaminophen group. The results of histopathological examination showed marked improvements in the appearance of the liver section of the omega-7 treated groups, as compared to the acetaminophen group. The results confirmed that Omega-7 has protective effects against acetaminophen-induced hepatotoxicity in rats. These positive effects could be attributable to omega-7’s potent anti-inflammatory and antioxidant properties.
