The Faculty of Pharmacy discussed the master’s thesis entitled “The possible protective effect of daflon in comparison with pentoxifylline against nephrotoxicity induced by cisplatin in experimental rats. The study aimed to reveal the protective effect of Daflon against cisplatin-induced nephrotoxicity and to compare it with pentoxifylline by evaluating the following parameters: blood urea nitrogen, creatinine, tumor necrosis factor-alpha, interleukin-6, serum levels of glutathione reductase in the kidneys, and malondialdehyde in addition to the histological examination of the rat section.The results showed that administration of Daflon in different doses to rats led to a significant decrease in the levels of urea and creatinine in the serum and a significant decrease in the activities of pro-inflammatory cytokines in the serum: tumor necrosis factor-alpha and interleukin-6, compared to the cisplatin group. Moreover, administration of Daflon in different doses to rats resulted in a significant increase in the activities of antioxidant enzymes (glutathione reductase enzyme) and a significant decrease in the level of malondialdehyde in the kidneys of rats compared to the cisplatin group. Also, by comparison with pentoxifylline in different doses, it was found that Daflon gave results similar to pentoxifylline. The histological examination showed a significant fading of the kidney sections of daflon-treated rats compared to the cisplatin group. The results proved that Daflon has a protective effect against cisplatin-induced nephrotoxicity through its anti-inflammatory and antioxidant effects, and that the low doses gave similar results to the high doses. It also recommends an experimental study of the use of Daflon for more periods of time.
