The Faculty of Pharmacy discussed the Master’s Degree thesis, tagged” The Faculty of Pharmacy discussed The Possible Protective Effect of Omega-7 Against Doxorubicin-Induced Cardiotoxicity in Male Rats” by Mohammed Haider Fadhel and the supervisor, Assist. Prof Dr. Ali Faris Hassan in the Department of Pharmacology and Toxicology. The thesis aimed to evaluate the possible protective effects of omega-7 against doxorubicin-induced cardiotoxicity in male rats. The concept of the thesis Data analysis revealed that Lactate dehydrogenase and creatinine kinase-myocardial brand showed a non-significant (p>0.05) change in group III (100mg/kg omega-7) compared to group I and a significant decrease in group IV (300mg/kg omega-7) compared to group II. Reactive oxygen species were significantly decreased in the omega-7 treated group when compared to the positive control group (p<0.05). Superoxide dismutase showed a non-significant difference in the omega-7 treated group compared to the positive control group (p>0.05). Catalase and glutathione peroxidase were significantly increased in the omega-7 treated groups when compared to the positive control group (p<0.05). malondialdehyde was significantly decreased in the omega-7 treated group when compared to the positive control group (p<0.05). Tumor necrosis factor-alpha, Interleukin-6, and interleukin-1beta were significantly decreased in the omega-7 treated groups (100 and 300mg/kg) compared to the positive control group (p<0.05). Histological examination revealed a significant improvement in the heart section of omega-7 treated groups compared to the doxorubicin-only group. This in vivo experimental study provides a piece of evidence for the possible protective effect of omega-7 in the amelioration of cardiac toxicity in doxorubicin-treated patients. The study recommends the determination of the exact molecular mechanism responsible for the antioxidant effect of omega-7, the evaluation of the possible protective effects of omega-7 on other vital organs, like the kidney, brain, and liver, and studying the antioxidant effects of omega-7 in comparison with other known antioxidants like vitamin E and omega-3.
