The Faculty of Pharmacy discussed the master’s degree thesis, entitled ” Association of deiodinase type 2 polymorphism with the response to levothyroxine therapy ” by Nada Hamid Rasheed and the supervisor, Lecturer Dr. Basma Zuheir Muhammed Naji in the Clinical Pharmacy Department. The thesis aimed to examine the influence of two single nucleotide polymorphisms of deiodinase type 2 (rs 225013) and (rs 225014) on levothyroxine dose requirements in patients with hypothyroidism and also to investigate the anxiety and depression levels in these patients. This was a cross-sectional study conducted at Baghdad Center for Nuclear Medicine and Radiation Therapy. A total of 60 hypothyroid patients receiving levothyroxine treatment participated in the study. The mean age of the participants was 40.35 ± 9.5 years with the highest percentage being females (85%).Patients who have had the wild type (TT) of the SNP (rs225014) required significantly higher levothyroxine doses with a mean of 151.47± 45.47 µg/day. The mean scores of anxiety and depression for the total sample were 8.72±3.46 and 7.8±2.83; respectively. The study has shown that genetic polymorphism of deiodinase type 2 enzyme can be associated with increased levothyroxine dose requirement. In addition, the study has shown that symptoms of anxiety and depression can still be present despite being on levothyroxine treatment and achieving the euthyroid state.
