The Faculty of Pharmacy discussed the Master’s Degree thesis, entitled Synthesis, Characterization, and Preliminary Antimicrobial Evaluation of New Isatin-Chalcone Conjugates by Hamza Fadhil Hamza, and the supervisor, Assist. Prof. May Mohammed Jawad Al-Mudhafar in the Pharmaceutical Chemistry Department. The study aimed to synthesize new isatin-chalcone conjugates 6(a–j) and 5-fluoroisatin-chalcone conjugates 9(a–g), which were synthesized in light of previous research that showed the modifications of the isatin moiety and its analogs led to the synthesis of many derivatives that have different biological activities. The synthesis of isatin-chalcone conjugates 6(a–j) was done through two routes, while the synthesis of 5-fluoroisatin-chalcone conjugates 9(a–g) was done through one route. Proton-nuclear magnetic resonance (¹H-NMR) and Fourier-transform infrared (FT-IR) spectroscopy were used to confirm the chemical structures of the newly prepared compounds. The final compounds were evaluated by the well diffusion technique for their antimicrobial activities against groups of Gram-positive and Gram-negative bacteria and against fungi, using amoxicillin, ciprofloxacin, and fluconazole, respectively, as standard drugs. For isatin-chalcone conjugates 6(a–j), the antimicrobial activity of compounds (6b and 6e) was more potent than that of other derivatives. While for 5-fluoroisatin-chalcone conjugates 9(a–g), the compounds (9d and 9e) were more potent than other derivatives. For both conjugates, the antifungal activity was better than the antibacterial activity.This study concluded that the newly prepared compounds showed moderate activity compared to amoxicillin and ciprofloxacin and moderate to high activity compared to fluconazole.
