The College of Pharmacy discussed the MSc thesis entitled “Preparation and Characterization of Dutasteride Nanoparticles as Fast Dissolving Oral Film” by the student Rusul Wahhab Kadhum and her supervisor, Prof. Dr. Shaimaa N. Abdulhameed, at the Pharmaceutics Department. The study aimed to prepare and characterize dutasteride nanoparticles to enhance their solubility and release rate, and then incorporate the nanoparticles into a fast-dissolving oral film to achieve fast release and rapid onset of action and to improve patient compliance. The results showed that dutasteride nanoparticles exhibited a significant improvement in dissolution rate, as in vitro dissolution studies revealed faster drug release, achieving 100% within 15 minutes. The study recommended the importance of conducting a clinical trial to assess the in vivo bioavailability of oral fast-dissolving films that include dutasteride nanoparticles. Moreover, it is crucial to conduct a comprehensive stability assessment over the long term to comprehend how temperature and humidity affect these films. Furthermore, further research and evaluations are essential to grasp patients’ preferences and tolerance towards oral fast-dissolving films with dutasteride nanoparticles, particularly when compared to the presently accessible dutasteride soft gelatin capsules.
