The College of Pharmacy discussed the MSc thesis entitled “Synthesis, characterization, and preliminary evaluation of anti-microbial activity for 6-mercaptopurine heterocyclic derivatives” by the student Noor Salah Hashim and Lecturer Dr. Muthanna Saadi Farhan at the Pharmaceutical Chemistry Department. The major aim of this research is to synthesize a new heterocyclic derivative of 6-mercaptopurine. The study involved the synthesis of new 6-mercaptoputine derivatives with a 2-aminobenzothiazole molecule or compound containing hydrazone and an oxadiazole moiety through a 6-mercaptopurine ester and 6-mercaptopurine hydrazide and evaluating their antibacterial activity using a well diffusion method and a minimum inhibition concentration test (MIC). The new product showed good activity against gram-positive and gram-negative bacteria, as well as antifungal activity. The study recommended doing additional research on pharmacodynamics and molecular docking studies, which is essential for determining the anti-inflammatory and biological effects, such as anticancer effects.
