The College of Pharmacy discussed the MSc thesis entitled “Preparation and Characterization of Isradipine as Surfactant free emulsion” by the student Zahraa Mohammed Naji and the supervisor, Associate Professor Dr. Fatima Jalal Jawad at the Pharmaceutics Department. The study aimed to prepare a stable, low-toxic, eco-friendly, and oral oil-in-water surfactant-free dry emulsion (SFDE) of isradipine for pediatric patients, protecting it from hydrolysis, oxidation, and photosensitivity and increasing its solubility. The study included the preparation of an Isradipine emulsion consisting of corn oil, grape seed oil, or a mixture of them in different ratios as the oil phase. The aqueous phase consisted of beta-cyclodextrin or chitosan in various proportions. The selected formulation was then dried using a lyophilizer to produce a dry emulsion powder free of emulsifiers. This powder was tested for solubility, flow properties, and other characteristics. The study concluded that surfactant-free emulsion (SFE) provides an important pediatric dosage form for oral administration of water-insoluble drugs, improving the dissolution rate and solubility of isradipine. The study recommended the use of solid particles to stabilize emulsions, which opens the door to various applications, such as controlled drug release, protection of sensitive materials through encapsulation, increased solubility and bioavailability, and improved taste and odor.
