The College of Pharmacy discussed the MSc thesis entitled “Synthesis, Characterization of New Isatin-Thiazole Derivatives with Preliminary Biological Activity” by the student Marwa Hashim Mohammad Hashim and the supervisor, Assistant Professor. May Mohammad Jawad, at the Pharmaceutical Chemistry Department. The study aimed to synthesize different Schiff bases of 2-aminothiazole and N-propargylated Mannich bases of isatin and predict their antimicrobial activity (AM1-AM5). Also, synthesize different N-Mannich bases of isatin conjugated to thiazole ring via imine linkage and predict their antimicrobial activity (MT1-MT5). The study included several Schiff and Mannich bases formed from isatin that were synthesized. Acetylenic Mannich bases (IIa-e) were prepared by a reaction of isatin with propargyl bromide and different secondary amines (morpholine, piperidine, pyrrolidine, dimethylamine, and diphenylamine) separately, and cuprous chloride (CuCl) was used as a catalyst. These Mannich bases were treated with 2-aminothiazole to obtain the desired final compounds (AM1-AM5). The FT-IR and 1H-NMR spectral data were used to characterize these synthesized compounds. Another number of Schiff and Mannich bases obtained from isatin were synthesized. First, Mannich bases (2a-e) were prepared by a reaction of isatin with formaldehyde and different secondary amines (morpholine, piperidine, pyrrolidine, diethylamine, and N-methylaniline) separately. These Mannich bases were also treated with 2-aminothiazole to obtain the desired final compounds (MT1-MT5). The antimicrobial activity of each of these derivatives was examined against two species of Gram+ve bacteria (Staphylococcus aureus and Bacillus licheniformis), two species of Gram-ve bacteria (Escherichia coli and Acinetobacter baumannii), and one species of fungus species (Candida albicans). The study concluded that most of the compounds were found to exhibit significant antimicrobial activity, and the most active are compounds AM1, MT5. The study recommended Screening for anti-inflammatory effects of different final Schiff base compounds. We are also testing the anticancer activity of acetylenic Mannich and Schiff bases.
