The Faculty of Pharmacy at the University of Baghdad, discussed the Msc. thesis tagged (Formulation and In-vitro Characterization of Nefopam Hydrochloride as mucoadhesive thermosensitive In-situ nasal gel) for the student in the Pharmaceutics Department, Ammar Abdulmajeed Ahmed Alabdly, and his supervisor, Assist.Prof.Dr. Hanan Jalal Kassab. The study aimed at the formulation of in-situ nasal gel as an alternative route for nefopam that, which is extensively metabolized in liver when taken orally. The thesis included using poloxamer 407 and 188 polymers as thermosensitive polymers and hyaluronic acid and methylcellulose as mucoadhesive polymers for preparation of in-situ nasal gel for administration of nefopam as a painkiller from nose to brain.The thesis also includes the evaluation of gelation temperature for formulated formulas and characterization of its appearance, drug content, compatibility, gel strength, viscosity, in-vitro drug release, and ex-vivo permeation study.The study showed the ability to formulate in-situ nasal gel by using the cold method and the effect of thermosensitive and mucoadhesive polymers on gelation temperature.
