The College of Pharmacy discussed the MSc thesis entitled “Preparation and Evaluation of Clozapine as Nanosuspension-Based Fast Dissolving Films” by the student Amal Abdullah Mohammed and the supervisor, Professor Dr. Shaimaa Nazar Abd-Alhammid, at the Pharmaceutics Department. This study’s main objective was to prepare and characterize clozapine nanosuspensions that enhance their solubility and release rate. Then clozapine nanoparticles were incorporated into a sublingual fast-dissolving film to avoid first-pass metabolism that may improve oral bioavailability. The study involved preparing clozapine nanosuspension by the solvent-antisolvent method, using different stabilizers at different ratios. The research investigated how various factors affected the particle size and the polydispersity index (PDI) of clozapine nanosuspension formulas. The optimized clozapine nanosuspension was incorporated into fast-dissolving sublingual films using the solvent casting method, employing a range of film-forming polymers and different plasticizers. The findings indicated that the optimal formula contained PVA as a polymer and PEG 400 as a plasticizer, which exhibited the shortest in-vitro disintegration time, within 13 seconds. Moreover, the in-vitro dissolution profile revealed the most rapid drug release, achieving 100% within only 3 minutes. The study concluded that the utilization of the solvent-antisolvent technique in the production of clozapine nanosuspension has demonstrated efficacy in improving the dissolution rate. In addition, the fast-dissolving clozapine films showed significant promise as a pharmaceutical delivery system by avoiding first-pass metabolism. The study recommended conducting a stability study for both nanosuspension and fast-dissolving films; clinical studies are also essential for the bioavailability assessment of the prepared formula.
