The College of Pharmacy discussed the MSc thesis entitled “Design, Synthesis and Preliminary Biological Activities Evaluation of New Ketoprofen Derivatives” by the student Rawaa Fadhil Abbas and the supervisor Assist. Prof. Dr. Muthanna Saadi Farhan, at the Pharmaceutical Chemistry Department.
The study aimed to design and synthesize new ketoprofen derivatives, including N-acyl hydrazone, thiosemicarbazone, and 1,2,4-triazole-3-thione compounds, and to evaluate their antibacterial and antifungal activities, in addition to in silico investigations such as molecular docking, molecular dynamics, and ADME studies.
The study included the synthesis of ketoprofen ester, which was subsequently converted into the corresponding hydrazide, followed by reactions with various aldehydes and isothiocyanates to obtain Schiff base and thiosemicarbazide derivatives, respectively. Further cyclization of these intermediates yielded triazole derivatives. The synthesized compounds were characterized by ATR-FTIR, ¹H-NMR, and ¹³C-NMR spectroscopy, and their antimicrobial activity was tested by inhibition zone and minimum inhibitory concentration (MIC) assay.
The study concluded that some synthesized compounds, particularly Fs2, RAF1, and Fs1, exhibited significant antibacterial and antifungal activity, accompanied by promising pharmacological properties, supported by molecular docking and ADME predictions.
The study recommended further advanced studies on these derivatives, including toxicity and biological evaluations, with the aim of developing them as potential drug candidates for combating resistant bacterial and fungal infections.
