The Faculty of Pharmacy discussed the Dotor’s Degree thesis, tagged” Synthesis and Biological Evaluation of Novel Benzodipyrone Based Derivatives” by Salah Hassan Zain Al Abdeen and the supervisor, Assist. Prof. Dr. Shihab Hattab Mutlag and Prof. Dr. Yasser Fakri Mustafa in the Pharmaceutical Chemistry Department. The thesis aimed to synthesize A novel series of benzodipyrone derivatives using a novel benzodipyrone core precursor, and their various biological activities were investigated. The pharmacological profiles of these benzodipyrones have almost been fully characterized by this study, which has clarified their therapeutic effects and provided direction for future efforts to improve them. The results of screening the anticancer activity showed that, when compared to other prepared compounds, the fluorinated derivatives (SY4, SY11, and SY18) had the most potent and widespread anticancer activity, with IC50 values that were close to the norm, particularly against the MCF-7 and HeLa cell lines. The synthesized chemicals were shown to be safer than the standard in terms of cytosafety. The fluorinated derivatives have the best safety record out of all of them. The findings from the analysis of the antimicrobial activities produced a number of intriguing findings. First, among other synthesized compounds, the chlorinated derivatives (SY5, SY12, and SY19) demonstrated the strongest antibacterial activity against all of the evaluated pathogenic aerobic gram-negative bacterial strains. Second, when compared to the standard, the synthesized compounds displayed a better level of safety for the evaluated non-pathogenic aerobic gram-negative bacterium model.. Third, among other synthesized compounds, the methoxy derivatives (SY2, SY9, and SY16) demonstrated the highest antibacterial activity toward all of the evaluated harmful anaerobic bacterial strains. Finally, more than half of the synthesized compounds outperformed the standard in their good antifungal activity against the two pathogenic fungal strains tested, with the benzodipyrone core precursors (SY1, SY8 and SY15) being the most effective .According to the results of detecting antidiabetic activity, the methoxy derivatives of benzodipyrone (SY2, SY9, and SY16) showed the highest suppressing impact against yeast-α-glucosidase and porcine-α-amylase enzymes compared to the other synthesized compounds, with potency similar to the standard. The antioxidative activity scan revealed that the methoxy derivatives of benzodipyrone cores (SY2, SY9, and SY16) had the strongest uptake effect on DPPH and hydroxyl free radicals, particularly in comparison to the synthesized benzodipyrone derivatives.
