The College of Pharmacy discussed the MSc thesis entitled “Preparation and Evaluation of Lercanidipine Hydrochloride Nanosuspension as a Sublingual Fast-Dissolving Film” by the student Zahraa Alaa Abass and the supervisor, Assistant Prof. Dr. Fatima J. Jawad, at the Pharmaceutics Department. The study aimed to prepare and characterize lercanidipine HCl nanosuspension to enhance the solubility and release rate and then incorporate the Nanosuspension into a fast-dissolving sublingual film to achieve fast release and rapid onset of action and to improve patient compliance. The results showed that lercanidipine HCl nanosuspension exhibited significant improvement in dissolution rate, as in vitro dissolution studies revealed faster drug release, achieving 100% within 20 minutes. The study recommended the importance of conducting a clinical trial to assess the in vivo bioavailability of sublingual fast-dissolving films that include lercanidipine HCl nanoparticles. Moreover, it is crucial to conduct a comprehensive stability assessment over the long term to comprehend how temperature and humidity affect these films. Furthermore, further research and evaluations are essential to grasp patients’ preferences and tolerance towards sublingual fast-dissolving films with lercanidipine HCl nanoparticles, particularly when compared to the presently accessible film-coated tablets of lercanidipine HCl.
